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Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial

  • Elizabeth V Cyarto1,
  • Nicola T Lautenschlager2, 3,
  • Patricia M Desmond4,
  • David Ames1, 2,
  • Cassandra Szoeke1, 5,
  • Olivier Salvado6,
  • Matthew J Sharman7,
  • Kathryn A Ellis1, 2, 8,
  • Pramit M Phal4,
  • Colin L Masters8, 9,
  • Christopher C Rowe10,
  • Ralph N Martins11 and
  • Kay L Cox12Email author
BMC Psychiatry201212:167

DOI: 10.1186/1471-244X-12-167

Received: 4 July 2012

Accepted: 28 September 2012

Published: 11 October 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
4 Jul 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
27 Sep 2012 Author responded Author comments - Elizabeth Cyarto
Resubmission - Version 3
27 Sep 2012 Submitted Manuscript version 3
28 Sep 2012 Editorially accepted
11 Oct 2012 Article published 10.1186/1471-244X-12-167

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

National Ageing Research Institute
Department of Psychiatry, Academic Unit for Psychiatry of Old Age, St. Vincent’s Health, The University of Melbourne
School of Psychiatry and Clinical Neurosciences and Western Australia Centre for Health & Ageing, University of Western Australia
Department of Radiology, Royal Melbourne Hospital and The University of Melbourne
Commonwealth Scientific and Industrial Research Organisation (CSIRO) Preventative Health Flagship
CSIRO Preventative Health Flagship ICT, Royal Brisbane and Women's Hospital
School of Exercise and Health Sciences, Edith Cowan University
Mental Health Research Institute, The University of Melbourne
Centre for Neuroscience, The University of Melbourne
Department of Nuclear Medicine and Centre for PET, Austin Hospital
School of Medical Sciences, Edith Cowan University
School of Medicine and Pharmacology, University of Western Australia