This manuscript was written on behalf of, and in consultation with, the 5-HTTLPR, Stress, and Depression Consortium, which consists of the following studies:
Avon Longitudinal Study of Parents and Children (ALSPAC), Athens Study of Psychosis Proneness and Incidence of Schizophrenia (ASPIS), University Mental Health Research Institute, Athens, Greece, Australian Temperament Project (ATP), BIGSIBS, Christchurch Health and Development Study (CHDS), Chinese Academy of Medical Sciences. Cognitive Function and Mood Study (CoFaMS), University of Adelaide, Collaborative Study on the Genetics of Alcoholism (COGA), Collaborative Genetic Study of Nicotine Dependence (COGEND), Community Twin and Longitudinal Twin Samples and National Youth and Family Study (CTS-LTS and NYFS), Depression Case–control study (DeCC), European Prospective Investigation into Cancer – Norfolk (EPIC-Norfolk), Enquête de Santé Psychologique – Risques, Incidence et Traitement Project (ESPRIT), The Genesis 12–19 Study (G1219), Genetic Study of Bipolar Disorder, GENESIS: GEnetics, NEuropsychology, functional neuroImaging of Suicidal behavior (Genetics Study of Suicidal Behaviour), Grady Trauma Project (GTP), Heart and Soul Study, Intern Health Study, Mannheim Study of Children at Risk (MARS), Michigan Longitudinal Study (MLS), MoodInflame (Münster), Universität Münster, Münster Neuroimaging Study, Universität Münster, Netherlands Study on Depression and Anxiety (NESDA), New molecules in mood disorders: a genomic, neurobiological and systems approach in animal models and human disorder (NEWMOOD), Netherlands Twin Register (Adult NTR and Young NTR), Personality And Total Health through life (PATH), Pregnancy Outcomes and Community Health Studies) – based 5-HTTLPR gene-environment interaction for meta-analysis (POUCH), CIBERSAM University of Granada, Spain (PREDICT-Gene), The Queensland Institute of Medical Research Twin and Family Study (QIMR Twin), Centre for Clinical Research, Västerås, Sweden. Survey of Adolescent Life in Vestmanland 2001 and 2006 (SALVe 2001 and SALVe 2006), Social Environment and Biomarkers of Aging Study (SEBAS), Study of Health in Pomerania (SHIP), TRacking Adolescents’ Individual Lives Survey (TRAILS), University of Bologna, Institute of Psychiatry, Department of Biomedical and Neuromotor Sciences, Bologna, Italy, University of Molise, Department of Health Sciences, Campobasso, Italy, and Victoria Adolescent Health Care Study (VAHCS).
The authors would like to acknowledge the following individuals, for their contributions to the development of the protocol and their roles in the creation of the participating studies:
Kaarin J. Anstey, Ricardo Araya, Volker Arolt, Cecilia Åslund, Gyorgy Bagdy, Tobias Banaschewski, Bernhard T. Baune, Dorret Boomsma, Daniel Brandeis, Peter Butterworth, Vladimir Carli, Jorge Cervilla, Helen Christensen, Sarah Cohen-Woods, Erika Comasco, Philippe Courtet, William L. Coventry, Udo Dannlowski, Eco de Geus, Bill Deakin, Katharina Domschke, Harmen Draisma, Simon Easteal, Thalia Eley, Anne Farmer, Helen L. Fisher, Ian Gotlib, Hans Jörgen Grabe, Blanca Gutiérrez, Brett Haberstick, John Hewitt, Amy Horton, John Horwood, Jouke-Jan Hottenga, Isabelle Jaussent, Anthony Jorm, Gabriella Juhasz, Manfred Laucht, Judit Lazary, Jerzy Leppert, Kathryn Lester, Keriann Little, Alain Malafosse, Laura Mandelli, Nicholas G. Martin, Peter McGuffin, Christel Middeldorp, Camelia Minica, Grant W. Montgomery, Matthias Nauck, Esther Nederhof, Kent W. Nilsson, Niklas Nordquist, Albertine J. Oldehinkel, Emilie Olié, Lars Oreland, Johan Ormel, Christian Otte, Brenda Penninx, Wouter Peyrot, Karen Ritchie, Bryan Rodgers, Marco Sarchiapone, Andrea Schulz, Christian Schwahn, Srijan Sen, Alessandro Serretti, Grant Sinnamon, Rickard L Sjöberg, Johannes Smit, Nicholas Stefanis, Paul Surtees, Sandra Villafuerte, Henry Völzke, Nick Wainwright, Mary Whooley, Gonneke Willemsen, Naomi R. Wray, and Robert A Zucker.
This work was supported by National Institutes of Health grants R21 DA033827 and R01 DA026911 from the National Institute on Drug Abuse, P01 CA089392 from the National Cancer Institute, and U10 AA008401 from the National Institute on Alcohol Abuse and Alcoholism.