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Table 1 Allele frequencies of the CTG repeat in controls and schizophrenic patients, including subtypes, course specifiers and positive family history, and results of Fisher's exact test and Monte Carlo method

From: The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals

      

Fisher's test

Monte Carlo

Subjects (n)

Alleles (%)

6R vs 9-13R

method

 

6R

9R

10R

11R

13R

P value

P value

Controls (100)

38 (19.0)

72 (36.0)

78 (39.0)

12 (6.0)

0 (0.0)

0.7095

0.9547

Schizophrenic patients (102)

42 (20.6)

67 (32.8)

80 (39.2)

14 (6.9)

1 (0.5)

0.7095

0.9547

   Subtypes

       

Paranoid (22)

10 (22.7)

13 (29.5)

17 (38.6)

4 (9.1)

0 (0.0)

0.5378

0.7538

Disorganized (38)

21 (27.6)

27 (35.5)

23 (30.3)

4 (5.3)

1 (1.3)

0.1392

0.3808

Residual (29)

8 (13.8)

18 (31.0)

28 (48.3)

4 (6.9)

0 (0.0)

0.4386

0.6666

Others (13)

3 (11.5)

9 (34.6)

12 (46.1)

2 (7.7)

0 (0.0)

0.4304

0.7869

   Course

       

Episodic (64)

24 (1 8.8)

48 (37.5)

45 (35.2)

10 (7.8)

1 (0.8)

1.0000

0.9207

Continuous (31)

15 (24.2)

15 (24.2)

28 (45.2)

4 (6.5)

0 (0.0)

0.3709

0.4709

Others (7)

3 (21.4)

4 (28.6)

7 (50.0)

0 (0.0)

0 (0.0)

0.7346

0.8137

Prominent negative symptoms (42)

17 (20.2)

26 (31.0)

34 (40.5)

6 (7.1)

1 (1.2)

0.8696

0.8388

   Positive family history (46)

19 (20.7)

31 (33.7)

34 (37.0)

7 (7.6)

1 (1.1)

0.7522

0.9002

  1. 6R, 9R, 10R, 11R and 13R indicate 6, 9, 10, 11 and 13 repeats of CTG, respectively.