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Table 1 Incidence and timing of signs and symptoms of post-injection delirium/sedation syndrome (PDSS) occurring with olanzapine long-acting injection

From: Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of cases

Clinical Symptoms of PDSS Events--Grouped

Presented Initially

N (%)

Occurred at Any Time

N (%)

Sedation (e.g., somnolence, sedation, unconsciousness)

12 (40)

26 (87)

Delirium (combined)

14 (47)

29 (97)

   Speech Impairment (e.g., dysarthria)

7 (23)

21 (70)

   Motor Impairment (e.g., ataxia)

7 (23)

12 (40)

   Cognitive Impairment (e.g., confusion, disorientation)

8 (27)

17 (57)

EPS, akathisia, tension or cramps in extremities

3 (10)

7 (23)

Agitation, aggression, irritability, anxiety, restlessnessa

2 (7)

9 (30)

General malaise (e.g., weak, dizzy, felt bad)

19 (63)

20 (67)

Hypertension

1 (3)

2 (7)

Possible seizure/convulsions

0 (0)

2 (7)

  1. Abbreviations: e.g. = for example; EPS = extrapyramidal symptoms; N = number of patients; PDSS = post-injection delirium/sedation syndrome.
  2. a Restlessness may also be a manifestation of EPS (akathisia).