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Figure 1 | BMC Psychiatry

Figure 1

From: Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism

Figure 1

Olanzapine plasma concentrations across multiple injections in a patient with a PDSS event. The figure illustrates the olanzapine plasma concentration profiles after 6 different olanzapine LAI injections in one patient who experienced a PDSS event at the second injection. Arrows below the x-axis indicate injections. Higher than expected olanzapine plasma concentrations were measured at 6 and 24 hours after the second injection, with concentrations returning to the expected therapeutic range after 48 hours. Olanzapine concentrations at subsequent injections remained in the expected therapeutic range. The dashed line indicates 100 ng/mL; all of the assessed PDSS cases had maximum olanzapine concentrations higher than this value.

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