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Table 1 Solubility of olanzapine pamoate monohydrate in various media determined at 24 and 48 hours (37°C)

From: Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism

Medium (time in hours)

Solubility (mg/mL)

Mean Solubility (mg/mL)

Plasma (24 hr)

0.986

0.918

   Repeat #1

0.935

 

   Repeat #2

0.832

 

Plasma (48 hr)

1.090

0.986

   Repeat #1

0.890

 

   Repeat #2

0.978

 

Plasma ultrafiltratea (24 hr)

0.150

0.187

   Repeat #1

0.236

 

   Repeat #2

0.176

 

Plasma ultrafiltrate (48 hr)

0.160

0.176

   Repeat #1

0.161

 

   Repeat #2

0.207

 

pH 7.68 buffer (24 hr)

0.058

0.052

   Repeat #1

0.053

 

   Repeat #2

0.044

 

pH 7.68 buffer (48 hr)

0.072

0.060

   Repeat #1

0.063

 

   Repeat #2

0.046

 

pH 6.80 buffer (24 hr)

0.024

0.013

   Repeat #1

0.007

 

   Repeat #2

0.008

 

pH 6.80 buffer (48 hr)

0.016

0.016

   Repeat #1

0.012

 

   Repeat #2

0.021

 
  1. aPlasma ultrafiltrate (i.e., plasma filtered for proteins and lipid particles) was used to assess the importance of the presence of proteins and lipids upon solubility and dissolution of olanzapine pamoate monohydrate
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BMC Psychiatry

ISSN: 1471-244X

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