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Table 1 Solubility of olanzapine pamoate monohydrate in various media determined at 24 and 48 hours (37°C)

From: Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism

Medium (time in hours) Solubility (mg/mL) Mean Solubility (mg/mL)
Plasma (24 hr) 0.986 0.918
   Repeat #1 0.935  
   Repeat #2 0.832  
Plasma (48 hr) 1.090 0.986
   Repeat #1 0.890  
   Repeat #2 0.978  
Plasma ultrafiltratea (24 hr) 0.150 0.187
   Repeat #1 0.236  
   Repeat #2 0.176  
Plasma ultrafiltrate (48 hr) 0.160 0.176
   Repeat #1 0.161  
   Repeat #2 0.207  
pH 7.68 buffer (24 hr) 0.058 0.052
   Repeat #1 0.053  
   Repeat #2 0.044  
pH 7.68 buffer (48 hr) 0.072 0.060
   Repeat #1 0.063  
   Repeat #2 0.046  
pH 6.80 buffer (24 hr) 0.024 0.013
   Repeat #1 0.007  
   Repeat #2 0.008  
pH 6.80 buffer (48 hr) 0.016 0.016
   Repeat #1 0.012  
   Repeat #2 0.021  
  1. aPlasma ultrafiltrate (i.e., plasma filtered for proteins and lipid particles) was used to assess the importance of the presence of proteins and lipids upon solubility and dissolution of olanzapine pamoate monohydrate