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Table 3 Symptom severity at Baseline and at Last Observation Carried Forward

From: Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula

   Bipolar   ADHD  
   symptom severity (range 0 to 48)   symptom severity (range 0 to 9)  
row # Data Sample Baseline Last Observation Carried Forward %change from Baseline effect size sample size: N = Baseline Last Observation Carried Forward %change from Baseline effect size sample size: N =
1 Primary Sample: Bipolar = sum of sub-samples #2 and #3      
  Mean 17.8 9.6 *** -46% 0.78 120 5.0 3.0 * -40% 0.62 29
  Median 17.4 7.1 -59%    5.0 3.0 -40%   
  Std. Deviation 10.1 8.3     2.9 2.2    
  Baseline-Median Split Sample: split by Baseline bipolar symptom severity split by Baseline ADHD symptom severity
1 Above Above Baseline Median:         
  Mean 25.1 12.9 *** -49% 1.21 60 7.5 3.1 *** -59% 1.72 14
  Median 24.0 10.9 -54%    7.0 3.0 -57%   
  Std. Deviation 6.1 9.4     1.1 2.7    
1 Below Below Baseline Median:         
  Mean 9.1 6.4 *** -30% 0.45 60 2.7 2.9 7% -0.10 15
  Median 8.7 5.6 -36%    3.0 3.0 0%   
  Std. Deviation 4.6 5.4     1.9 1.8    
1 Older Age 12 or above:           
  Mean 17.1 9.3 *** -46% 0.81 70 4.4 2.2 ** -50% 0.67 15
  Median 16.0 7.1 -55%    4.0 1.4 -65%   
  Std. Deviation 10.5 8.2     2.4 2.1    
1 Younger Age younger than 12:         
  Mean 17.1 10.2 *** -41% 0.73 50 5.7 3.8 * -33% 0.54 14
  Median 17.6 6.9 -61%    7.0 3.4 -51%   
  Std. Deviation 8.6 8.5     3.3 2.2    
1 Male Male: Mean 17.4 10.3 *** -41% 0.67 71 4.9 3.0 ** -39% 0.59 21
  Male: Median 17.0 7.2 -58%    5.0 3.0 -40%   
  Std. Deviation 8.9 8.8     3.1 2.1    
1 Female Female: Mean 18.3 8.7 *** -53% 0.94 49 5.4 3.1 -43% 0.64 8
  Female: Median 17.8 6.2 -65%    6.7 2.5 -63%   
  Std. Deviation 9.3 7.5     2.5 2.7    
2 Sub-Sample: Bipolar but not ADHD         
  Mean 16.7 9.4 *** -44% 0.80 91      
  Median 15.7 6.6 -58%        
  Std. Deviation 9.9 8.3         
3 Sub-Sample: Bipolar and ADHD         
  Mean 18.2 10.3 *** -43% 0.72 29 5.0 3.0 ** -40% 0.62 29
  Median 20.0 8.6 -57%    5.0 3.0 -40%   
  Std. Deviation 9.0 8.3     2.9 2.2    
4 Alternative Sample: ADHD but not bipolar         
  Mean       6.0 3.2 *** -47% 1.04 41
  Median       6.7 2.8 -58%   
  Std. Deviation       2.5 2.6    
  1. Notes: *** indicates that mean LOCF is significantly different from mean at Baseline, at level p < .001; ** at level p < .01; *at level p < .05