Figure 1

Schizophrenia is a complex multigenetic disease. Schizophrenia may be seen as the result of a multifaceted interplay between multiple causative factors, including several genetic markers and a variety of different environmental risks. Cases with a critical genetic load may not need additional external/environmental co-factors, whilst in others, the interaction of a certain genetic predisposition with environmental co-factors is required for disease onset (modified from [84]).