Figure 4

Least Squares (LS) Mean Changes in Baseline PANSS Marder Anxiety/Depression Factor Score. (A) Patients with baseline MADRS total scores ≥20; (B) patients with baseline CGI-BP-D severity scores ≥4; (C) patients with a mixed episode at baseline. CGI-BP-D = Clinical Global Impression for Bipolar Disorder-Depression scale; MADRS = Montgomery-Asberg Depression Rating Scale; PANSS = Positive and Negative Syndrome Scale. Error bars represent SE. *P < 0.05; ^† P ≤ 0.01; ^‡ P ≤ 0.001 vs placebo. ^†† P ≤ 0.01 vs olanzapine.