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Table 2 Descriptive Statistics of Efficacy Variables (KUSTA, IDS-C, Pain VAS, SSI) Over Time

From: Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine

Variable

Baseline (N = 4517)

2 Weeks (N = 4242)

4 Weeks (N = 3991)

3 Months (N = 3681)

6 Months (N = 3320)

Mean KUSTA score a , mean (SD)

25.2 (16.8)

34.4 (20.3)

43.3 (23.3)

53.1 (24.7)

58.9 (25.9)

IDS-C total score, mean (SD)

39.2 (12.4)

31.8 (13.0)

25.2 (12.8)

19.9 (12.6)

16.1 (11.9)

VAS (mm), mean (SD)

     

Overall pain

55.0 (26.6)

44.9 (25.5)

39.1 (25.6)

34.2 (25.4)

30.5 (25.4)

   Headache

40.8 (31.7)

34.3 (29.7)

30.1 (28.2)

27.2 (27.2)

23.7 (25.6)

   Back pain

50.3 (31.7)

40.8 (30.1)

35.9 (28.9)

32.9 (28.5)

29.7 (27.9)

   Joint pain

48.5 (32.3)

38.8 (30.0)

34.3 (28.7)

31.4 (28.4)

28.4 (28.3)

   Shoulder/neck pain

43.9 (32.8)

34.5 (29.6)

30.2 (28.4)

27.7 (28.1)

24.5 (27.0)

   Chest pain

24.8 (28.7)

19.7 (25.1)

17.0 (23.1)

15.8 (22.5)

14.5 (21.5)

   Abdomen pain

24.4 (28.4)

20.2 (24.8)

17.3 (23.0)

16.6 (22.8)

14.5 (20.9)

≥ 30% reduction in VAS overall pain:

All patients, n (%)

NA

1279 (31.9)

1771 (46.9)

1968 (56.2)

1949 (61.9)

   Females, n (%)

NA

913 (31.8)

1277 (47.2)

1419 (56.4)

1392 (61.6)

   Males, n (%)

NA

366 (32.1)

494 (46.0)

549 (55.6)

557 (62.6)

   Patients with > 30 mm in VAS overall pain at baseline

NA

1060 (32.8)

1492 (48.8)

1689 (59.4)

1664 (65.4)

≥ 50% reduction in VAS overall pain:

All patients, n (%)

NA

705 (17.6)

1129 (29.9)

1427 (40.7)

1516 (48.1)

   Females, n (%)

NA

500 (17.4)

811 (30.0)

1019 (40.5)

1075 (47.6)

   Males, n (%)

NA

205 (18.0)

318 (29.6)

408 (41.3)

441 (49.6)

   Patients with > 30 mm in VAS overall pain at baseline

NA

539 (16.7)

910 (29.8)

1193 (42.0)

1273 (50.1)

SSI, mean (SD)

     

Total score

2.47 (0.69)

2.20 (0.68)

2.00 (0.66)

1.84 (0.66)

1.72 (0.65)

Painful symptoms

2.76 (0.88)

2.43 (0.84)

2.23 (0.81)

2.04 (0.79)

1.90 (0.77)

Non-painful symptoms

2.38 (0.69)

2.13 (0.67)

1.92 (0.65)

1.77 (0.66)

1.65 (0.64)

  1. KUSTA = Kurz-Skala Stimmung/Aktivierung; N = Total number of available patients (number of patients with available data varied depending on variable and visit); SD = Standard deviation. NA = Not applicable; SD = Standard deviation; SSI = Somatic Symptom Inventory; VAS = Visual analogue scales.
  2. a Mean of KUSTA scores items mood, activity, tension/relaxation and sleep,, range: score 0-100
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BMC Psychiatry

ISSN: 1471-244X

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