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Table 3 Logistic regression of factors associated with at least one prescription of cholinesterase inhibitors in the incidence year and characteristics of ChEI users vs.non-users

From: Impact of geriatric comorbidity and polypharmacy on cholinesterase inhibitors prescribing in dementia

Characteristics ChEI users
(n = 241)
Non-users
(n = 1,607)
Proportion of ChEI user
(n = 1,848)
Model 1a)
ORcrude (95% CI)
Model 2b)
ORadj (95% CI)
Age groups, in years      
   65-74 107 (44.4%) 459 (28.6%) 18.9% 3.32 (2.13-5.18) 1.41 (0.85-2.34)
   75-84 107 (44.4%) 763 (47.5%) 12.3% 2.00 (1.29-3.10) 1.30 (0.81-2.11)
   85+ 27 (11.2%) 385 (24.0%) 6.6% 1 1
Sex      
   Male 137 (56.8%) 832 (51.8%) 14.1% 1.23 (0.93-1.61) 0.89 (0.65-1.21)
   Female 104 (43.2%) 775 (48.2%) 11.8% 1 1
Area of residence*      
   Urban 168 (69.7%) 1161 (72.3%) 12.6% 1 1
   Rural 73 (30.3%) 444 (27.7%) 14.1% 1.14 (0.85-1.53) 1.48 (1.06-2.06)
Number of prescribed medications
   Q1 (0-6) 90 (37.3%) 520 (32.4%) 14.8% 1.43 (0.97-2.10) 0.93 (0.58-1.49)
   Q2 (7-9) 59 (24.5%) 352 (21.9%) 14.4% 1.38 (0.91-2.10) 1.03 (0.64-1.65)
   Q3 (10-13) 48 (19.9%) 372 (23.1%) 11.4% 1.06 (0.69-1.64) 0.79 (0.49-1.28)
   Q4 (14+) 44 (18.3%) 363 (22.6%) 10.8% 1 1
Level of care dependency
   None 161 (66.8%) 866 (53.9%) 15.7% 5.83 (1.82-18.61) 5.35 (1.61-17.81)
   1 41 (17.0%) 341 (21.2%) 10.7% 3.77 (1.14-12.44) 4.32 (1.26-14.75)
   2 36 (14.9%) 306 (19.0%) 10.5% 3.69 (1.11-12.24) 3.97 (1.16-13.60)
   3 3 (1.2%) 94 (5.8%) 3.1% 1 1
Symptom complexes characterizing geriatric patients
   0 33 (13.7%) 115 (7.2%) 22.3% 3.46 (1.87-6.41) 4.23 (2.06-8.69)
   1-2 120 (49.8%) 707 (44.0%) 14.5% 2.05 (1.22-3.44) 2.52 (1.41-4.50)
   3-4 70 (29.0%) 568 (35.3%) 11.0% 1.49 (0.87-2.55) 1.59 (0.89-2.84)
   5+ 18 (7.5%) 217 (13.5%) 7.7% 1 1
Contacts to neurologists/psychiatrists
   0 43 (17.8%) 981 (61.0%) 4.2% 1 1
   1-2 16 (6.6%) 151 (9.4%) 9.6% 2.42 (1.33-4.40) 2.53 (1.37-4.65)
   3-5 44 (18.3%) 137 (8.5%) 24.3% 7.33 (4.64-11.57) 7.86 (4.88-12.66)
   6-9 84 (34.9%) 141 (8.8%) 37.3% 13.59 (9.04-20.43) 14.05 (9.14-21.59)
   10+ 54 (22.4%) 197 (12.3%) 21.5% 6.25 (4.07-9.60) 7.66 (4.85-12.11)
  1. a) crude models
  2. b) multivariate model adjusted for all other variables
  3. * missing values for 2 patients for which classification into the urban or rural group was not possible