Table 3 Categorical changes in weight and laboratory values at endpoint
OLZ LAI 150 n/N (%) | OLZ LAI 405 n/N (%) | OLZ LAI 300 n/N (%) | Cochran-Armitage p-value | ||
|---|---|---|---|---|---|
Weight | ≥7% gain | 17/140 (12.14) | 34/315 (10.79) | 24/140 (17.14) | .127 |
≥7% loss | 9/140 (6.43) | 13/315 (4.13) | 7/140 (5.00) | .720 | |
Fasting glucose | Normal to borderline | 14/75 (18.67) | 37/176 (21.02) | 25/89 (28.09) | .121 |
Normal/borderline to high | 5/106 (4.72) | 6/244 (2.46) | 4/108 (3.70) | .855 | |
Normal to high | 1/75 (1.33) | 2/176 (1.14) | 0/89 (0) | .311 | |
Borderline to high | 4/31 (12.90) | 4/68 (5.88) | 4/19 (21.05) | .320 | |
Fasting HDL | Normal to low | 8/58 (13.79) | 26/133 (19.55) | 19/62 (30.65) | .019 |
Fasting LDL | Normal to borderline | 6/26 (23.08) | 15/66 (22.73) | 5/18 (27.78) | .702 |
Normal to high | 0/26 (0) | 0/66 (0) | 0/18 (0) | ------- | |
Borderline to high | 6/53 (11.32) | 14/129 (10.85) | 9/73 (12.33) | .804 | |
Fasting total cholesterol | Normal to borderline | 9/48 (18.75) | 15/133 (11.28) | 10/51 (19.61) | .607 |
Normal to high | 0/48 (0) | 2/133 (1.50) | 2/51 (3.92) | .127 | |
Borderline to high | 4/34 (11.76) | 13/65 (20.00) | 5/35 (14.29) | .959 | |
Fasting triglycerides | Normal to borderline | 13/62 (20.97) | 17/133 (12.78) | 9/53 (16.98) | .713 |
Normal to high | 2/62 (3.23) | 8/133 (6.02) | 10/53 (18.87) | .001 | |
Normal to extremely high | 0/62 (0) | 0/133 (0) | 1/53 (1.89) | .082 | |
Borderline to high | 3/14 (21.43) | 11/38 (28.95) | 3/18 (16.67) | .556 | |
Borderline to extremely high | 0/14 (0) | 0/38 (0) | 1/18 (5.56) | .114 | |
Prolactin | Normal to high (females) | 2/17 (11.76) | 9/42 (21.43) | 7/21 (33.33) | .112 |
Normal to high (males) | 4/49 (8.16) | 16/116 (13.79) | 7/52 (13.46) | .523 |