Effect | Ziprasidone Hazard Ratio (95% CI) | Olanzapine Hazard Ratio (95% CI) | Quetiapine Hazard Ratio (95% CI) | Risperidone Hazard Ratio (95% CI) |
---|---|---|---|---|
Age | 0.992 (0.973-1.011) | 0.997 (0.981-1.014) | 0.994 (0.978-1.011) | 0.988 (0.971-1.005) |
Women vs. Men | 1.164 (0.720-1.882) | 0.755 (0.510-1.118) | 1.269 (0.837-1.924) | 0.776 (0.524-1.149) |
Charlson Comorbidity Index | 1.220 (1.024-1.454)* | 1.054 (0.876-1.267) | 0.801 (0.548-1.171) | 1.109 (0.958-1.284) |
Prior Psychiatric Hospitalization | 2.910 (1.888-4.484)*** | 3.541(2.408-5.207)*** | 3.874 (2.703-5.553)*** | 2.287 (1.579-3.314)*** |
Prior Diabetes | 0.838 (0.338-2.076) | 0.885 (0.358-2.189) | 2.222 (0.943-5.232) | 1.149 (0.550-2.400) |
Prior Hyperlipidemia | 0.913 (0.446-1.317) | 0.614 (0.324-1.165) | 0.895 (0.508-1.579) | 1.327(0.776-2.268) |
Prior Lipid Test | 0.677 (0.348-1.317) | 0.715 (0.412-1.243) | 1.307 (0.779-2.194) | 0.687(0.397-1.189) |
Prior Glucose Test | 1.172 (0.742-1.849) | 1.409 (0.928-2.141) | 0.792 (0.519-1.210) | 1.476 (0.969-2.248) |
Pre-index mood stabilizer | ||||
   1 vs. none | 1.177 (0.648-2.138) | 1.194 (0.679-2.098) | 1.489 (0.904-2.451) | 1.197(0.697-2.056) |
   2 vs. none | 0.765 (0.270-2.171) | 0.689 (0.280-1.691) | 1.487 (0.704-3.142) | 1.250(0.552-2.831) |
   ≥ 3 vs. none | 0.331 (0.035-3.137) | 1.068 (0.291-0.919) | 0.617 (0.073-5.217) | 0.301(0.035-2.567) |
Post-index mood stabilizer | ||||
   Carbamazepine | 3.853 (1.623-9.151)** | 2.191(0.988-4.859) | 1.242 (0.579-2.661) | 1.926(0.879-4.219) |
   Lamotrigine | 1.268 (0.640-2.514) | 1.233 (0.649-2.344) | 0.844 (0.486-1.465) | 1.482(0.853-2.573) |
   Lithium | 0.716 (0.317-1.619) | 2.287(1.249-4.188)** | 0.710 (0.377-1.339) | 1.029(0.556-1.904) |
   Oxcarbazepine | 1.660 (0.740-3.726) | 1.266 (0.607-2.640) | 0.469 (0.201-1.092) | 0.877(0.422-1.824) |
   Topiramate | 1.256 (0.536-2.943) | 1.699 (0.847-3.407) | 0.800 (0.422-1.518) | 1.362(0.697-2.663) |
   Valproate | 0.811 (0.399-1.652) | 0.754 (0.402-0.414) | 0.438 (0.235-0.814)** | 0.679(0.364-1.266) |
Year of Index Prescription | 0.963 (0.733-1.266) | 1.047 (0.814-0.345) | 0.773 (0.617-0.969) | 0.758(0.604-0.952)* |
Comparator vs. Aripiprazole | 1.962 (1.269-3.033)** | 1.554 (1.035-1.333)* | 1.556 (1.078-2.245)* | 1.368(0.940-1.989) |