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Table 3 Adjusted Cox proportionate hazards models (aripiprazole reference)

From: One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis

Effect Ziprasidone
Hazard Ratio
(95% CI)
Olanzapine
Hazard Ratio
(95% CI)
Quetiapine
Hazard Ratio
(95% CI)
Risperidone
Hazard Ratio
(95% CI)
Age 0.992 (0.973-1.011) 0.997 (0.981-1.014) 0.994 (0.978-1.011) 0.988 (0.971-1.005)
Women vs. Men 1.164 (0.720-1.882) 0.755 (0.510-1.118) 1.269 (0.837-1.924) 0.776 (0.524-1.149)
Charlson Comorbidity Index 1.220 (1.024-1.454)* 1.054 (0.876-1.267) 0.801 (0.548-1.171) 1.109 (0.958-1.284)
Prior Psychiatric Hospitalization 2.910 (1.888-4.484)*** 3.541(2.408-5.207)*** 3.874 (2.703-5.553)*** 2.287 (1.579-3.314)***
Prior Diabetes 0.838 (0.338-2.076) 0.885 (0.358-2.189) 2.222 (0.943-5.232) 1.149 (0.550-2.400)
Prior Hyperlipidemia 0.913 (0.446-1.317) 0.614 (0.324-1.165) 0.895 (0.508-1.579) 1.327(0.776-2.268)
Prior Lipid Test 0.677 (0.348-1.317) 0.715 (0.412-1.243) 1.307 (0.779-2.194) 0.687(0.397-1.189)
Prior Glucose Test 1.172 (0.742-1.849) 1.409 (0.928-2.141) 0.792 (0.519-1.210) 1.476 (0.969-2.248)
Pre-index mood stabilizer
   1 vs. none 1.177 (0.648-2.138) 1.194 (0.679-2.098) 1.489 (0.904-2.451) 1.197(0.697-2.056)
   2 vs. none 0.765 (0.270-2.171) 0.689 (0.280-1.691) 1.487 (0.704-3.142) 1.250(0.552-2.831)
   ≥ 3 vs. none 0.331 (0.035-3.137) 1.068 (0.291-0.919) 0.617 (0.073-5.217) 0.301(0.035-2.567)
Post-index mood stabilizer
   Carbamazepine 3.853 (1.623-9.151)** 2.191(0.988-4.859) 1.242 (0.579-2.661) 1.926(0.879-4.219)
   Lamotrigine 1.268 (0.640-2.514) 1.233 (0.649-2.344) 0.844 (0.486-1.465) 1.482(0.853-2.573)
   Lithium 0.716 (0.317-1.619) 2.287(1.249-4.188)** 0.710 (0.377-1.339) 1.029(0.556-1.904)
   Oxcarbazepine 1.660 (0.740-3.726) 1.266 (0.607-2.640) 0.469 (0.201-1.092) 0.877(0.422-1.824)
   Topiramate 1.256 (0.536-2.943) 1.699 (0.847-3.407) 0.800 (0.422-1.518) 1.362(0.697-2.663)
   Valproate 0.811 (0.399-1.652) 0.754 (0.402-0.414) 0.438 (0.235-0.814)** 0.679(0.364-1.266)
Year of Index Prescription 0.963 (0.733-1.266) 1.047 (0.814-0.345) 0.773 (0.617-0.969) 0.758(0.604-0.952)*
Comparator vs. Aripiprazole 1.962 (1.269-3.033)** 1.554 (1.035-1.333)* 1.556 (1.078-2.245)* 1.368(0.940-1.989)
  1. * p < 0.05
  2. **p < 0.01
  3. ***p < 0.001