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Table 3 Adjusted Cox proportionate hazards models (aripiprazole reference)

From: One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis

Effect

Ziprasidone

Hazard Ratio

(95% CI)

Olanzapine

Hazard Ratio

(95% CI)

Quetiapine

Hazard Ratio

(95% CI)

Risperidone

Hazard Ratio

(95% CI)

Age

0.992 (0.973-1.011)

0.997 (0.981-1.014)

0.994 (0.978-1.011)

0.988 (0.971-1.005)

Women vs. Men

1.164 (0.720-1.882)

0.755 (0.510-1.118)

1.269 (0.837-1.924)

0.776 (0.524-1.149)

Charlson Comorbidity Index

1.220 (1.024-1.454)*

1.054 (0.876-1.267)

0.801 (0.548-1.171)

1.109 (0.958-1.284)

Prior Psychiatric Hospitalization

2.910 (1.888-4.484)***

3.541(2.408-5.207)***

3.874 (2.703-5.553)***

2.287 (1.579-3.314)***

Prior Diabetes

0.838 (0.338-2.076)

0.885 (0.358-2.189)

2.222 (0.943-5.232)

1.149 (0.550-2.400)

Prior Hyperlipidemia

0.913 (0.446-1.317)

0.614 (0.324-1.165)

0.895 (0.508-1.579)

1.327(0.776-2.268)

Prior Lipid Test

0.677 (0.348-1.317)

0.715 (0.412-1.243)

1.307 (0.779-2.194)

0.687(0.397-1.189)

Prior Glucose Test

1.172 (0.742-1.849)

1.409 (0.928-2.141)

0.792 (0.519-1.210)

1.476 (0.969-2.248)

Pre-index mood stabilizer

   1 vs. none

1.177 (0.648-2.138)

1.194 (0.679-2.098)

1.489 (0.904-2.451)

1.197(0.697-2.056)

   2 vs. none

0.765 (0.270-2.171)

0.689 (0.280-1.691)

1.487 (0.704-3.142)

1.250(0.552-2.831)

   ≥ 3 vs. none

0.331 (0.035-3.137)

1.068 (0.291-0.919)

0.617 (0.073-5.217)

0.301(0.035-2.567)

Post-index mood stabilizer

   Carbamazepine

3.853 (1.623-9.151)**

2.191(0.988-4.859)

1.242 (0.579-2.661)

1.926(0.879-4.219)

   Lamotrigine

1.268 (0.640-2.514)

1.233 (0.649-2.344)

0.844 (0.486-1.465)

1.482(0.853-2.573)

   Lithium

0.716 (0.317-1.619)

2.287(1.249-4.188)**

0.710 (0.377-1.339)

1.029(0.556-1.904)

   Oxcarbazepine

1.660 (0.740-3.726)

1.266 (0.607-2.640)

0.469 (0.201-1.092)

0.877(0.422-1.824)

   Topiramate

1.256 (0.536-2.943)

1.699 (0.847-3.407)

0.800 (0.422-1.518)

1.362(0.697-2.663)

   Valproate

0.811 (0.399-1.652)

0.754 (0.402-0.414)

0.438 (0.235-0.814)**

0.679(0.364-1.266)

Year of Index Prescription

0.963 (0.733-1.266)

1.047 (0.814-0.345)

0.773 (0.617-0.969)

0.758(0.604-0.952)*

Comparator vs. Aripiprazole

1.962 (1.269-3.033)**

1.554 (1.035-1.333)*

1.556 (1.078-2.245)*

1.368(0.940-1.989)

  1. * p < 0.05
  2. **p < 0.01
  3. ***p < 0.001