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Table 2 Percentage of subjects displaying each of the 17 side effects of methylphenidate during each treatment condition (Parent Ratings)*

From: Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD

Side Effect

Total Side Effects

Severe Side Effects

 

Placebo

Active

P-value

Placebo

Active

P-value

Insomnia (%)

25

47

0,00

7

13

0,08

Nightmares (%)

15

12

0,39

2

1

0,68

Stares a lot (%)

26

31

0,30

4

4

0,96

Talks less (%)

13

23

0,01

2

4

0,49

Uninterested (%)

15

14

0,69

2

3

0,46

Decreased Appetite (%)

20

49

0,00

4

17

0,00

Irritable (%)

52

54

0,68

12

10

0,57

Stomachaches (%)

17

25

0,10

4

4

0,92

Headaches (%)

19

31

0,01

2

8

0,02

Drowsiness (%)

8

14

0,09

0

2

0,08

Sadness (%)

27

30

0,57

4

8

0,09

Prone to crying (%)

32

43

0,05

7

6

0,88

Anxious (%)

37

34

0,54

7

4

0,25

Bites fingernails (%)

21

22

0,86

8

8

0,76

Euphoria (%)

31

20

0,03

8

5

0,21

Dizziness (%)

7

5

0,39

0

1

0,15

Tics/Nervous

movements (%)

14

15

0,93

4

2

0,33

  1. * % refers to the percentage of subjects in whom the side effect was rated 1 or higher on the scale of severity (1 to 9); % severe refers to the percentage of subjects in whom the side effect was rated 7 or higher.
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BMC Psychiatry

ISSN: 1471-244X

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