Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder

Table 5 SLC6A4 and PTSD effects on mean ROI activation and working memory performance⁵

⁵The p-value(s) are from the omnibus F-test for a general linear model (GLM) that includes genotype, diagnosis (PTSD status) and genotype*diagnosis product (interaction) term. Factors include diagnosis (2 levels; PTSD, control) and genotype with 2 or 3 levels (see Table 2). Covariates are race (African American or European American), score on the Beck Depression Inventory (BDI; see Table 1) and antidepressant medication dose equivalents (see Table 3). Significance level was adjusted by multiplying by the number of effective multiple comparisons (seven) that was calculated with the Nyholt correction.
⁶left amygdala (p_corr = .07), right amygdala (p_corr >.2).
Abbreviations: region of interest (ROI), dorsolateral prefrontal cortex (dlPFC), lateral parietal cortex (LPC).

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