Structural brain changes in first episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis

Olabi, Bayanne; Ellison-Wright, Ian; Bullmore, Ed; Lawrie, Stephen M

doi:10.1186/1471-244X-12-104

Table 2 Regions of gray matter decreases in FES and FTLD subjects compared with controls

From: Structural brain changes in first episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis

Cluster	Region		Talairach coordinates			Value	Volume (mm³)
			x	y	z
FIRST EPISODE SCHIZOPHRENIA
1	R/L	Caudate	2	14	0	0.0046	1624
	R	Caudate	10	10	12	0.0017
2	L	Uncus	−18	−2	−22	0.0031	1272
	L	Amygdala	−12	0	−14	0.0028
3	R	Superior temporal gyrus	48	−24	10	0.0019	400
	R	Superior temporal gyrus	48	−26	16	0.0018
4	L	Insula	−36	20	6	0.0025	376
5	L	Transverse temporal gyrus	−46	−18	10	0.0021	288
6	R	Middle temporal gyrus	54	−26	−2	0.0022	272
7	L	Superior temporal gyrus	−58	−26	12	0.0021	272
8	L	Superior temporal gyrus	−56	2	−4	0.0021	216
9	R	Insula	36	8	10	0.0021	216
10	R	Parietal lobe: Postcentral gyrus	54	−20	44	0.0022	216
11	L	Frontal lobe: Middle frontal gyrus	−30	50	4	0.002	200
12	L	Frontal lobe: Inferior frontal gyrus	−22	28	−6	0.0018	184
13	L	Parietal lobe: Postcentral gyrus	−60	−18	20	0.002	184
14	R	Amygdala / Uncus	20	−4	−22	0.002	168
15	L	Superior temporal gyrus	−32	14	−22	0.0019	152
16	L	Inferior temporal gyrus	−46	−14	−18	0.002	152
17	L	Cingulate gyrus	−8	−4	38	0.002	152
18	R	Insula / Claustrum	34	−14	12	0.0018	136
19	R	Medial frontal gyrus (BA 8)	14	34	36	0.0017	136
20	L	Cingulate gyrus	0	−42	38	0.0016	112
21	R	Medial frontal gyrus (BA 6)	6	6	48	0.0017	112
FRONTO-TEMPORAL LOBE DEGENERATION
1	R	Amygdala / Uncus	22	−4	−20	0.0029	3744
	R	Globus Pallidus region	20	2	−4	0.0024
	R	Hippocampus / Parahippocampus	28	−20	−10	0.0015
2	L	Amygdala / Parahippocampus	−22	−6	−16	0.0027	2336
	L	Globus Pallidus region	−18	0	−6	0.0025
	L	Uncus	−26	−4	−28	0.002
3	L	Anterior cingulate	−2	10	−4	0.0024	2144
	L	Caudate	−8	10	10	0.0022
	L	Caudate	−6	2	14	0.0015
4	L	Frontal lobe: Medial frontal gyrus (BA 9)	−4	48	24	0.003	1256
5	L	Frontal lobe: Inferior frontal gyrus	−36	24	4	0.0022	936
	L	Insula	−38	14	0	0.0016
6	L	Superior temporal gyrus	−42	12	−14	0.0021	896
	L	Superior temporal gyrus	−44	2	−12	0.0018
7	R	Frontal lobe: Inferior frontal gyrus	42	16	−12	0.003	880
8	L	Frontal lobe: Middle frontal gyrus	−44	8	38	0.0032	784
9	R	Frontal lobe: Inferior frontal gyrus	42	16	12	0.0025	768
10	L	Frontal lobe: Superior frontal gyrus	−22	60	2	0.0023	704
	L	Frontal lobe: Superior frontal gyrus	−24	56	12	0.0017
11	R	Cingulate gyrus	16	26	36	0.0025	576
12	R	Insula	42	−6	−4	0.0021	568
13	L	Temporal lobe: fusiform gyrus	−42	−30	−18	0.0027	520
14	L	Frontal lobe: Middle frontal gyrus	−22	18	50	0.0027	496
15	L	Anterior cingulate	−2	32	16	0.002	400
16	R	Caudate	8	12	12	0.0024	376
17	R	Middle temporal gyrus	48	2	−28	0.0024	312
18	L	Frontal lobe: Inferior frontal gyrus	−40	52	2	0.0024	232
19	L	Frontal lobe: Middle frontal gyrus	−28	34	−14	0.002	224
20	L	Insula	−42	2	0	0.0017	216
21	L	Parietal lobe (BA 7)	−20	−46	58	0.0023	216
22	L	Frontal lobe: Medial frontal gyrus (BA 10)	0	54	−4	0.0018	192
23	R	Superior temporal gyrus	28	14	−30	0.0016	176
24	L	Uncus	−34	−16	−34	0.0017	136
25	R	Cerebellum: Anterior lobe	48	−36	−28	0.0023	136
26	R	Frontal lobe: Middle frontal gyrus	36	44	8	0.0017	120
27	R	Uncus	28	−10	−32	0.0016	112

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