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Table 2 Percentages of the most frequent and selected general adverse events reported for different long-acting antipsychotic drugs

From: Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

Drug FL R R R R, in no r R in r R R vs oral R R R y R a R R R R V Z
Reference [131] [15] [79] [86] [84] [84] [85] [88] [89] [90] [91] [91] [105] [107] [132] [133] [88] [76]
n 16 715 192 202 312 82 1476 100 40 249 66 351 336 725 87 529 565 19
Anxiety 12.5 12 12 15 28.7 24.5 6.9 11.0 --- 11 21 23 22.3 26 16.1 23.9 --- ---
Insomnia 6.2 10 9 9 26.5 25.0 7.0 9.0 5.0 6 29 19 23.5 22 16.1 18.7 --- 8
Disease exacerbation --- --- 10 --- 20.1 15.8 6.1 5.0 --- 6 12 12 18.2 15 19.5 7.4 --- ---
Depressive reactions 17 --- 6 --- 19.8 15.7 --- 5.0 --- --- 17 14 19.3 15 --- 11.3 --- 25
Headache --- --- --- --- 14.7 14.7 --- --- 2.5 6 21 11   --- 11.5 7.7 --- ---
GI symptomsa --- --- --- --- --- --- --- --- --- --- 11 3 --- --- --- --- --- 17
Glucose-related AEs --- --- --- 0.5b --- --- --- --- --- --- --- --- --- --- 0.0 0.8c 0.0 ---
Prolactin-related AEsd --- --- --- 0.5 --- --- --- 6.0 2.5f 2.8 --- --- --- --- --- --- 0.4e ---
Sedation/Somnolence --- --- --- --- --- --- --- --- --- --- 12 5 --- --- --- --- --- ---
Rhinitis --- --- --- --- --- --- --- --- --- --- 18 11 --- --- --- --- --- ---
Fatigue --- --- --- --- --- --- --- --- --- --- 15 7 --- --- --- --- --- ---
Others 6.2h --- --- --- --- --- --- --- 2.5g,h --- --- --- --- --- --- --- --- 17h
  1. Abbreviations: FL = flupenthixol; R = risperidone; r = remission; y = in young patients; a = in adult patients; V = various; Z = zuclopenthixol decanoate; GI = gastrointestinal; AEs = adverse events; --- = not reported.
  2. aIncludes dyspepsia, nausea, and vomiting.
  3. bNew onset type 2 diabetes mellitus (n = 1).
  4. cNew onset type 2 diabetes mellitus (n = 3) and hyperglycemia (n = 1).
  5. dIncludes loss of libido, sexual impotence, galactorrhea, and gynecomastia.
  6. eImpotence (n = 1) and galactorrhea (n = 1).
  7. fIrregular menstruation (n = 1).
  8. gDisturbances in accommodation.
  9. hDizziness.