Drug | FL | R | R | R | R, in no r | R in r | R | R vs oral | R | R | R y | R a | R | R | R | R | V | Z |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference | [131] | [15] | [79] | [86] | [84] | [84] | [85] | [88] | [89] | [90] | [91] | [91] | [105] | [107] | [132] | [133] | [88] | [76] |
n | 16 | 715 | 192 | 202 | 312 | 82 | 1476 | 100 | 40 | 249 | 66 | 351 | 336 | 725 | 87 | 529 | 565 | 19 |
Anxiety | 12.5 | 12 | 12 | 15 | 28.7 | 24.5 | 6.9 | 11.0 | --- | 11 | 21 | 23 | 22.3 | 26 | 16.1 | 23.9 | --- | --- |
Insomnia | 6.2 | 10 | 9 | 9 | 26.5 | 25.0 | 7.0 | 9.0 | 5.0 | 6 | 29 | 19 | 23.5 | 22 | 16.1 | 18.7 | --- | 8 |
Disease exacerbation | --- | --- | 10 | --- | 20.1 | 15.8 | 6.1 | 5.0 | --- | 6 | 12 | 12 | 18.2 | 15 | 19.5 | 7.4 | --- | --- |
Depressive reactions | 17 | --- | 6 | --- | 19.8 | 15.7 | --- | 5.0 | --- | --- | 17 | 14 | 19.3 | 15 | --- | 11.3 | --- | 25 |
Headache | --- | --- | --- | --- | 14.7 | 14.7 | --- | --- | 2.5 | 6 | 21 | 11 | --- | 11.5 | 7.7 | --- | --- | |
GI symptomsa | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 11 | 3 | --- | --- | --- | --- | --- | 17 |
Glucose-related AEs | --- | --- | --- | 0.5b | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 0.0 | 0.8c | 0.0 | --- |
Prolactin-related AEsd | --- | --- | --- | 0.5 | --- | --- | --- | 6.0 | 2.5f | 2.8 | --- | --- | --- | --- | --- | --- | 0.4e | --- |
Sedation/Somnolence | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 12 | 5 | --- | --- | --- | --- | --- | --- |
Rhinitis | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 18 | 11 | --- | --- | --- | --- | --- | --- |
Fatigue | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 15 | 7 | --- | --- | --- | --- | --- | --- |
Others | 6.2h | --- | --- | --- | --- | --- | --- | --- | 2.5g,h | --- | --- | --- | --- | --- | --- | --- | --- | 17h |