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Table 1 Baseline predictors associated with categorical improvement after 6 Months and 12 Months of treatment with OLAI

From: Schizophrenia symptoms and functioning in patients receiving long-term treatment with olanzapine long-acting injection formulation: a pooled analysis

  Logistic regression statistics
Model Odds ratio 95% CI of Odds ratio p-value (for effect)
Single variable model 6 Months
 Age [1 year] 0.989 0.975; 1.002 0.0937
 Time since diagnosis [1 year] 0.979 0.959; 0.998 0.0327
 Working status    
  unemployed vs. retired 1.023 0.620; 1.688 0.9287
  working vs. retired 1.564 0.925; 2.644 0.0948
 Clinical Study    
  HGKA vs. HGKB 1.890 1.262; 2.830 0.0020
  HGLQ vs. HGKB 0.972 0.603; 1.566 0.9068
 Baseline category    
  C vs. B 3.007 1.966; 4.600 <0.0001
  D vs. B 6.656 4.386; 10.099 <0.0001
  E vs. B 3.043 1.585; 5.841 0.0008
 CGI-S [1 point higher at baseline] 0.787 0.659; 0.941 0.0084
 PANSS total [1 point higher at baseline] 1.010 1.000; 1.020 0.0622
  PANSS positive 1.553 1.210; 1.992 0.0005
  PANSS anxiety/depression 1.326 1.066; 1.649 0.0111
  PANSS hostility 1.253 0.992; 1.583 0.0586
 QLS total [1 point higher at baseline] 1.135 1.035; 1.245 0.0072
  QLS Instrumental role funct. 1.151 1.026; 1.291 0.0162
  QLS Interpersonal relations 1.159 1.008; 1.333 0.0381
 Remission baseline [yes vs, no] 1.061 0.778; 1.449 0.7078
 Remission 6 months [yes vs. no] 2.420 1.670; 3.507 <0.0001
Stepwise multivariate logistic regression 6 Months    
 PANSS positive 2.840 1.834; 4.399 <0.0001
 CGI-S 0.619 0.463; 0.828 0.0012
Single variable model 12 Months
 Clinical Study    
  HGKA vs. HGKB 1.592 1.048; 2.418 0.0294
  HGLQ vs. HGKB 0.905 0.562; 1.458 0.6811
 Baseline category    
  C vs. B 3.316 2.085; 5.271 <0.0001
  D vs. B 6.936 4.351; 11.057 <0.0001
  E vs. B 5.879 2.742; 12.605 <0.0001
 PANSS total 1.018 1.006; 1.029 0.0024
  PANSS positive 1.798 1.354; 2.387 <0.0001
  PANSS anxiety/depression 1.370 1.066; 1.761 0.0141
  PANSS disorganized 1.390 1.062; 1.821 0.0167
  PANSS hostility 1.565 1.193; 2.053 0.0012
 QLS total 1.157 1.045; 1.281 0.0049
  QLS Instrumental role funct. 1.178 1.038; 1.337 0.0112
  QLS Interpersonal relations 1.167 0.999; 1.363 0.0520
 Remission baseline 1.013 0.720; 1.426 0.9391
 Remission 12 months 2.628 1.710; 4.039 <0.0001
Stepwise multivariate logistic regression 12 Months    
 PANSS positive 1.537 1.129; 2.093 0.0063
  1. In total, 22 variables were assessed in the single variable logistic regression models. Variables in bold were identified as potentially overlapping variables and were not included in the stepwise multivariate logistic regression model. CGI-S: Clinical Global Impression – Severity, CI: confidence interval, PANSS: Positive and Negative Symptoms Score, QLS: Heinrich Carpenter’s Quality of Life Scale.