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Table 1 Frequency of prescriptions in mono- and combination therapy for classes of psychotropic substances

From: Mono- and combination drug therapies in hospitalized patients with bipolar depression. Data from the European drug surveillance program AMSP

 

1994 - 1997

1998 - 2001

2002 - 2005

2006 - 2009

Overall

N

%

N

%

N

%

N

%

N

%

Number of patients

248

 

454

 

711

 

832

 

2246

 

Number of patients monotherapy

53

21.4

99

21.8

85

12.0

97

11.7

334

14.9

Number of patients combination therapy

195

78.6

355

78.2

626

88.0

735

88.3

1912

85.1

Antidepressants

monotherapy

33

13.3

54

11.9

41

5.8

43

5.2

171

7.6

 

combination therapy

172

69.4

317

69.8

531

74.7

634

76.2

1655

73.7

Antipsychotics

monotherapy

8

3.2

16

3.5

16

2.3

30

3.6

70

3.1

 

combination therapy

97

39.1

194

42.7

418

58.8

534

64.2

1244

55.4

Anticonvulsants

monotherapy

6

2.4

16

3.5

15

2.1

14

1.7

51

2.3

 

combination therapy

65

26.2

177

39.0

402

56.5

425

51.1

1069

47.6

Lithium

monotherapy

6

2.4

13

2.9

13

1.8

10

1.2

42

1.9

 

combination therapy

105

42.3

152

33.5

204

28.7

275

33.1

736

32.8