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Table 4 Diagnostic features of NMS

From: Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report

Documented diagnostic feature of NMS

All NMS patients (n = 4)

Cases 1–5 “rapid dose escalators” (n = 5)

Cases 6–13 “non rapid dose escalators” (n = 8)

Pyrexia n (%)

5 (38.5)

1 (20)

4 (50)

Muscle Rigidity n (%)

10 (76.9)

3 (60)

7 (87.5)

Elevated CK n (%)

12 (100)1

4 (100)1

8 (100)

Mean CK U/l

2343.0

1672.5

2678.3

Altered GCS n (%)

12 (92.3)

4 (80)

8 (100)

Tachycardia n (%)

11 (84.6)

5 (100)

6 (75)

Mutism n (%)

7 (53.8)

2 (40)

5 (62.5)

Labile BP n (%)

6 (46.1)

1 (20)

5 (62.5)

Diaphoresis n (%)

8 (61.5)

2 (40)

6 (75)

Incontinence n (%)

6 (46.2)

1 (20)

5 (62.5)

Tremor n (%)

3 (23.1)

1 (20)

2 (25)

  1. 1information missing (diagnosed based on other criteria).