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Table 2 Baseline score and group change in behavior after treatment with TJ-54 for 12 weeks

From: Yokukansan (TJ-54) for treatment of pervasive developmental disorder not otherwise specified and Asperger’s disorder: a 12-week prospective, open-label study

   Baseline Group 12-week Group Group Mean p1
   Baseline Group 12-week Group Group Mean p1
Measure   Mean SD Mean SD Mean SD  
CGI-S   6.78 0.83 1.95 0.11 -4.825 0.46 <.0001
ABC-I (Irritability) 17.4 3.66 0.925 0.971 -16.5 1.46 <.0001
ABC-Total   77.8 11.4 6.90 4.84 -70.9 5.21 <.0001
  Lethargy 23.7 3.68 2.10 1.87 -21.6 1.78 <.0001
  Stereotypy 9.23 3.78 1.33 1.37 -7.90 1.55 <.0001
  Hyperactivity 21,7 3.90 1.83 1.89 -19.9 1.67 <.0001
  Inappropriate speech 5.78 1.25 0.73 0.75 -5.05 0.631 <.0001
  1. 1 Significance by t test.
  2. 2 Negative values indicate a positive change.