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Table 3 Plasma pharmacokinetic parameters of paliperidone following injections of paliperidone palmitate (150 mg eq.) (pharmacokinetic analysis set)

From: A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia

    Geometric Ratio Confidence Interval
PK parameter Injection N LSM (Test/Reference)a (90%)
AUCτ, ng.h/mL 2nd injection 96 21924.25   
  8th injection 96 26638.65 121.50 (114.42;129.03)
  14th injection 96 31522.41 143.78 (135.39;152.68)
Cmax, ng/mL 2nd injection 99 46.74   
  8th injection 99 49.42 105.75 (98.82;113.16)
  14th injection 99 57.74 123.55 (115.46;132.21)
Note: Data analyzed on log-scale but transformed back to the original scale
LSM = Least-Squares Means
  1. a Test refers to 8th/14th injection and Reference refers to 2nd injection