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Table 4 Tabular results for the external validation: distribution for PE% and |PE|% to assess bias and precision respectivelya

From: A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia

  Nb Observed
Median
Median cut-off to pass validation Observed 25th percentile Observed 75th percentile
Prediction error percents (PE%) 5382 0.72 ± 15 -9.37 10.47
Absolute prediction error percents (|PE|%) 5382 9.96 30 4.55 17.65
  1. a The prediction error percents (PE%) were computed for each concentration value using the equation below and the absolute prediction error percents (|PE|%) was computed as the absolute value of the PE%. PE% ij = (DV ij - PRED ij )/PRED ij * 100, where, PE% ij is the percent prediction error between the i th value of the dependent variable in the j th subject; and the population prediction of the i th observation in the j th subject; DV ij is the value of the i th observation (i.e. the dependent variable) in the j th subject; and PREDij is the population prediction of the i th observation in the j th subject.
  2. bN refers to the number of pharmacokinetic samples used in the calculation of the PE% and |PE|% statistics. The 5382 pharmacokinetic samples were derived from 211 patients.