Figure 1From: Frontal lobe changes occur early in the course of affective disorders in young people VBM grey matter results. Group difference, grey matter volume maps rendered on the MNI152 structural template. Statistically significant clusters of grey matter changes calculated using 23 patients at stage 1 (i.e. help-seeking/attenuated syndrome), 24 patients at stage 2/3 (i.e. discrete disorder/persistent or recurrent illness) and 33 healthy control subjects. Contrast 1 depicts healthy control subjects versus stage 1 subjects (grey matter loss occurring at stage 1 is presented in orange). Contrast 2 depicts healthy controls versus stage 2/3 (grey matter loss is presented in blue). Finally contrast 3 depicts grey matter volume changes in stage 1 versus stage 2/3 subjects (regions of significant grey matter loss are presented in green). Abbreviations are as follows: SFG = superior frontal gyrus; OFC = orbito frontal cortex; IFG = inferior frontal gyrus; MFG = middle frontal gyrus; ACG = anterior cingulate gyrus; Cing = cingulate; Ins = insula; Amyg = amygdala; MedFC = medial frontal gyrus; Caud = caudate; PHG = parahippocampal gyrus; SCC = subcallosal cortex. Images are radiologically oriented.Back to article page