Skip to main content

Table 3 Grey matter results

From: Frontal lobe changes occur early in the course of affective disorders in young people

Cortical Area Hemisphere MNI Coordinates Brodmann Area Cluster size (mm3) Corrected p-value
Healthy Control vs Attenuated Sydnrome
Amygdala right 28, -8, -14   2894 0.05
Precuneus right 14, -74, 34 7 3710 0.05
Insula left -42, -8, -8 13, 14 4156 0.05
Healthy Control vs Discrete Disorder
Middle frontal gyrus right 26, 46, 34 46 9088 0.01
Anterior cingulate cortex midline 0, 36, 12 24 6748 0.01
Inferior frontal gyrus right 46, 40, 10 10 4034 0.01
Caudate nucleus (head) right 6, 12, 2   1799 0.01
Caudate nucleus (head) left -6, 12, 2   1907 0.01
Parahippocampal gyrus left -10, -42, 2 36 2019 0.01
Insula left -36, -24, 12 13, 14 5973 0.01
Medial prefrontal cortex midline 0, 32, -16 9 9634 0.002
Orbitofrontal cortex midline 0, 34, -26 10 9858 0.01
Subcallosal cortex midline 0, 10, -8   7590 0.01
Attenuated Sydnrome vs Discrete Disorder
Superior frontal gyrus right 26, 30, 38 8, 9 8942 0.01
Middle frontal gyrus right 36, 30, 24 46 7429 0.01
Middle frontal gyrus left -24, 22, 40 46 3830 0.01
Inferior frontal gyrus right 40, 40, 8 10 6861 0.01
Inferior frontal gyrus left -46, 36, 8 10 4102 0.01
Anterior cingulate cortex right 2, 40, 20 24 3642 0.02
Orbitofrontal cortex right 26, 54, -4 10 4296 0.01
Medial prefrontal cortex midline 0, 22, 20 9 3487 0.004
  1. Results of significant clusters of grey matter volume loss for the right and left hemispheres for the following contrasts: (i) healthy controls vs attenuated syndrome, (ii) healthy controls vs discrete disorder and (iii) attenuated syndrome vs discrete disorder. Cortical coordinates are reported in MNI space, and cluster size in mm3