Frontal lobe changes occur early in the course of affective disorders in young people

BMC Psychiatry

Table 3 Grey matter results

Cortical Area	Hemisphere	MNI Coordinates	Brodmann Area	Cluster size (mm³)	Corrected p-value
Healthy Control vs Attenuated Sydnrome
Amygdala	right	28, -8, -14		2894	0.05
Precuneus	right	14, -74, 34	7	3710	0.05
Insula	left	-42, -8, -8	13, 14	4156	0.05
Healthy Control vs Discrete Disorder
Middle frontal gyrus	right	26, 46, 34	46	9088	0.01
Anterior cingulate cortex	midline	0, 36, 12	24	6748	0.01
Inferior frontal gyrus	right	46, 40, 10	10	4034	0.01
Caudate nucleus (head)	right	6, 12, 2		1799	0.01
Caudate nucleus (head)	left	-6, 12, 2		1907	0.01
Parahippocampal gyrus	left	-10, -42, 2	36	2019	0.01
Insula	left	-36, -24, 12	13, 14	5973	0.01
Medial prefrontal cortex	midline	0, 32, -16	9	9634	0.002
Orbitofrontal cortex	midline	0, 34, -26	10	9858	0.01
Subcallosal cortex	midline	0, 10, -8		7590	0.01
Attenuated Sydnrome vs Discrete Disorder
Superior frontal gyrus	right	26, 30, 38	8, 9	8942	0.01
Middle frontal gyrus	right	36, 30, 24	46	7429	0.01
Middle frontal gyrus	left	-24, 22, 40	46	3830	0.01
Inferior frontal gyrus	right	40, 40, 8	10	6861	0.01
Inferior frontal gyrus	left	-46, 36, 8	10	4102	0.01
Anterior cingulate cortex	right	2, 40, 20	24	3642	0.02
Orbitofrontal cortex	right	26, 54, -4	10	4296	0.01
Medial prefrontal cortex	midline	0, 22, 20	9	3487	0.004

Results of significant clusters of grey matter volume loss for the right and left hemispheres for the following contrasts: (i) healthy controls vs attenuated syndrome, (ii) healthy controls vs discrete disorder and (iii) attenuated syndrome vs discrete disorder. Cortical coordinates are reported in MNI space, and cluster size in mm³

ISSN: 1471-244X