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Table 1 Clinical characteristics of bipolar disorder (BD) inpatients with therapy-resistant depression

From: Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression

Variable

Total sample

BD I

BD II

p

   

n = 19

n = 32

 

Demographics

Gender (male), n (%)

24 (47.1)

7 (36.8)

17 (53.1)

0.201)

 

Age (years)

45.7 (10.5)

49.2 (9.2)

43.6 (10.8)

0.062)

 

Education (years)

13.8 (3.2)

12.6 (3.2)

14.5 (3.0)

0.04 2)

 

Premorbid IQ

112.9 (3.7)

112.0 (3.9)a

113.5 (3.4)b

0.182)

Course of illness

Duration of illness (years)

30.6 (11.4)

33.4 (9.4)a

29.1 (12.2)

0.192)

 

Hospitalizations due to depressive episodes

4.3 (3.9)

4.7 (4.8)c

4.1 (3.5)d

0.823)

 

History of psychotic symptoms, n (%)

24 (48.0)

16 (84.2)

8 (25.8)e

<0.01 1)

 

Number of psychotic episodes

1.8 (3.0)

3.6 (3.6)c

0.8 (2.1)f

<0.01 3)

Lifetime DSM-IV-TR diagnosis

Substance abuse, n (%)

15 (29.4)

6 (31.6)

9 (28.1)

1.001)

 

Anxiety, n (%)

14 (29.2)

8 (47.1)g

6 (19.4)e

0.061)

Symptom rating scales

MADRS

37.0 (6.6)

36.8 (6.6)

37.2 (6.6)

0.872)

 

PANSS pos

9.8 (3.4)

9.7 (3.6)c

9.8 (3.4)

0.763)

 

GAF-S

37.3 (10.9)

41.0 (9.8)a

35.3 (11.1)

0.103)

  1. Data are mean (SD) values unless otherwise specified for total group and groups with BD I or BD II subtype, accompanied by p values for statistical comparisons between subtypes: 1)chi-square test; 2)independent-samples t-test; 3)Mann-Whitney Test. Data presented in bold, p < 0.05.
  2. SD, Standard deviation; MADRS, Montgomery and Åsberg depression rating scale; PANSS pos, Positive and negative syndrome scale for schizophrenia, positive subscale; GAF-S, Global assessment of functioning–split version, symptom subscale; DSM-IV-TR, Diagnostic and statistical manual of mental disorders, fourth edition, text revision.
  3. a n = 18, b n = 28, c n = 15, d n = 30, e n = 31, f n = 29, g n = 17.