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Table 2 Test performance (T-scores) for the total sample, BD I and BD II subsamples in inpatients with therapy-resistant BD depression on nine cognitive tasks from the MCCB, six domain scores and mean composite score, and IQ, and change in IQ from the estimated premorbid level

From: Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression

Neurocognitive domain

Total sample

BD I

BD II

ANOVA

  Test

n = 51

n = 19

n = 32

F

p

η 2

 

Mean (SD)

Mean (SD)

Mean (SD)

   

Speed of processing

36.5 (12.3)

32.3 (14.6)

39.0 (10.2)

3.69

0.061)

0.07

  BACS–Symbol Coding

37.0 (11.7)

35.0 (13.6)

38.2 (10.5)

 

0.672)

 

  Fluency

44.7 (9.5)

40.7 (10.5)

47.1 (8.1)

5.91

0.02 1)

0.11

  TMT-A

37.7 (13.1)

33.7 (13.5)

40.0 (12.6)

2.77

0.101)

0.05

Attention/Vigilance

40.7 (11.4)a

38.5 (11.8)b

41.8 (11.3)c

0.78

0.381)

0.02

  CPT

      

Working memory

43.5 (11.2)

41.2 (11.1)

45.0 (11.3)

1.37

0.251)

0.03

  Spatial Span

45.9 (10.6)d

44.2 (10.8)

47.0 (10.5)e

0.80

0.381)

0.02

  Letter-Number Span

43.5 (10.7)

41.2 (10.7)

44.9 (10.7)

1.45

0.241)

0.03

Verbal learning

38.4 (8.1)

36.5 (7.6)

39.5 (8.2)

1.73

0.191)

0.03

  HVLT-R

      

Visual learning

43.0 (11.7)f

40.7 (13.7)g

44.3 (10.4)h

1.04

0.311)

0.02

  BVMT-R

      

Reasoning

42.3 (9.3)d

41.9 (7.8)g

42.4 (10.1)

 

0.812)

 

  Mazes

      

Mean composite score

40.6 (8.4)

38.4 (9.3)

41.9 (7.7)

2.19

0.141)

0.04

IQ

102.3 (13.6)

93.9 (15.2)

107.2 (10.2)

14.05

<0.01 1)

0.22

  WASI

      

IQ difference

10.8 (13.0)i

18.0 (13.7)g

6.1 (10.3)j

11.29

<0.01 1)

0.20

  NART-WASI

      
  1. Note: Scores on the MCCB measures have a mean of T = 50 and an SD of T = 10. IQ scores have a mean of 100 and an SD of 15. p values for statistical comparisons between BD subtypes: 1)ANOVA; 2)Mann-Whitney Test. Data presented in bold, p < 0.05.
  2. MCCB, Measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery; ANOVA, Analysis of variance; BACS, Brief assessment of cognition in schizophrenia; TMT-A, Trail-making test, part A; CPT, Continuous performance test; HVLT-R, Hopkins verbal learning test–revised; BVMT-R, Brief visuospatial memory test–revised; WASI, Wechsler abbreviated scale of intelligence; NART, National adult reading test.
  3. a n = 44, b n = 14, c n = 30, d n = 50, e n = 31, f n = 49, g n = 18, h n = 31, i n = 46, j n = 28 due to missing data.