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Table 2 Distribution of OPRM1 genotypes and alleles between SZ cases and controls in all, female and male samples*

From: Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population

SNP

Haplotype/Allele

All

   

Male

   

Female

   
  

Controls

Cases

OR (95%)

P value

Controls

Cases

OR (95%)

P value

Controls

Cases

OR (95%)

P value

rs799971

AA

68

132

1.00(referent)

 

31

93

1.00(referent)

 

37

39

1.00(referent)

 
 

AG

133

102

0.417(0.281-0.618)

<0.00001

85

50

0.208(0.121-0.358)

<0.00001

48

52

1.063(0.582-1.941)

0.84

 

GG

63

30

0.257(0.152-0.436)

<0.00001

30

11

0.127(0.057-0286)

<0.0.00001

33

19

0.564(0.273-1.164)

0.12

 

A

269

366

1.00(referent)

 

147

236

1.00(referent)

 

122

130

1.00(referent)

 
 

G

259

162

0.46(0.357-0.59)

<0.00001

145

72

0.309(0.218-0.439)

<0.00001

114

90

0.741(0.511-1.073)

0.11

 

HWE(P)

0.9

0.14

  

0.4

1.00

  

0.37

0.68

  

rs2075572

CC

140

166

1.00(referent)

 

79

84

1.00(referent)

 

61

82

1.00(referent)

 
 

CG

100

82

0.697(0.481-1.010)

0.06

51

55

1.053(0.643-1.725)

0.84

49

27

0.383(0.213-0.689)

0

 

GG

24

16

0.594(0.301-1.171)

0.59

16

15

0.951(0.437-2.071)

0.9

8

1

0.087(0.01-0.723)

0.02

 

C

380

414

1.00(referent)

 

209

223

1.00(referent)

 

171

191

1.00(referent)

 
 

G

148

114

0.707(0.534-0.937)

0.02

83

85

0.96(0.672-1.371)

0.82

65

29

0.399(0.246-0.648)

<0.00001

 

HWE(P)

0.32

0.68

  

0.96

0.91

  

0.56

0.68

  

rs648893

CC

107

116

1.00(referent)

 

55

69

1.00(referent)

 

52

47

1.00(referent)

 
 

CT

113

110

0.888(0.61-1.292)

0.54

59

57

0.755(0.453-1.259)

0.28

54

53

1.102(0.631-1.925)

0.73

 

TT

44

38

0.76(0.455-1.268)

0.29

32

28

0.671(0.36-1.253)

0.21

12

10

0.848(0.331-2.171)

0.73

 

C

327

342

1.00(referent)

 

169

195

1.00(referent)

 

158

147

1.00(referent)

 
 

T

201

186

0.885(0.689-1.137)

0.34

123

113

0.796(0.573-1.105)

 

78

73

1.006(0.681-1.486)

0.98

 

HWE(P)

0.13

0.06

  

0.96

0.84

  

0.38

0.21

  

rs671531

AA

102

109

1.00(referent)

 

56

68

1.00(referent)

 

46

41

1.00(referent)

 
 

AG

116

122

0.968(0.665-1.408)

0.87

63

69

0.893(0.544-1.465)

0.65

53

53

1.091(0.613-1.942)

0.77

 

GG

46

33

0.628(0.37-1.065)

0.09

27

17

0.482(0.237-0.981)

0.04

19

16

0.902(0.406-2.004)

0.8

 

A

320

340

1.00(referent)

 

175

205

1.00(referent)

 

145

135

1.00(referent)

 
 

G

208

188

0.851(0.663-1.092)

0.2

117

103

0.752(0.539-1.048)

0.09

91

85

1.003(0.688-1.463)

0.99

 

HWE(P)

0.2

0.08

  

0.95

1.00

  

0.67

1.00

  
  1. *According to the method of multiplicity correction for SNPs in LD that was introduced by Li & Ji [54], we considered p-values < 0.01 as significant.