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Table 1 Selected characteristics of randomised controlled studies examining the effect s of CCBT for adult depression

From: Is computerised CBT really helpful for adult depression?-A meta-analytic re-evaluation of CCBT for adult depression in terms of clinical implementation and methodological validity

First author and year of publication Rrecruitent Intervention, number of modules N Outcome measures Function measures Control group F-U Attrition rate (%) Imputation Country
Andersson (2005) [36] community guided iCBT, 5 117 BDI, MADRS QOL WL (online discussion group) 6 months 27% LOCF Sweden
Christensen (2004) [37] community unguided iCBT, 5 525 CES-D na Attention placebo 6 weeks 20% LOCF Australia
Clarke (2002) [38] vio HMO unguided iCBT, 7 299 CES-D na TAU 8 months 41% unclear USA
Clarke (2005)a vio HMO unguided iCBT, 7 + postcard-reminder 175 CES-D SF-12 TAU 16 weeks 34% REML USA
Clarke (2005)b vio HMO unguided iCBT, 7 + telepone-reminder 180 CES-D SF-12 TAU 16 weeks 34% REML USA
Clarke (2009) [39] vio HMO unguided iCBT, 4 160 PHQ-8 na TAU 8 months 37% REML USA
de Graaf (2009) [40] community unguided iCBT, 8 or 9 303 BDI-ii SF-36 TAU 6 months 5% MI the Netherlands
Meyer (2009) [41] community guided iCBT, 8 396 BDI WSAS WL 6 months 31% replaced by pretreatment scores German
Perini (2009) [42] community guided iCBT, 8 45 PHQ-9, BDI-ii SDS WL 8 weeks 27% replaced by pretreatment scores Australia
Ruwaard (2009) [43] community guided iCBT, 11Weeks 54 BDI WBQ WL 18 months 9% WOCF the Netherlands
Spek (2007) [44] community unguide iCBT, 8 301 BDI-ii, EDS na WL 2 weeks 40% MI the Netherlands
Titov (2009)a community technician-guided iCBT, 8 81 PHQ-9, BDI-ii SDS WL 16 weeks 8% LOCF Australia
Titov (2009)b community clinician-guided iCBT, 8 86 PHQ-9, BDI-ii WBQ WL 16 weeks 8% LOCF Australia
van Straten (2008) [45] community guided iCBT, 4 213 CESD, MDI EuroQoL WL 4 weeks 17% MI the Netherlands
Venrnmark (2010) [46] community guided iCBT, 8 88 BDI, MADRS QOL WL 6 months 14% LOCF Sweden
Warmerdam (2008) [47] community guided iCBT, 8 263 CESD EuroQoL WL 12 weeks 40% LMM the Netherlands
  1. iCBT, Internet-based Cognitive Behavioural Therapy; cCBT, Computer-based Cognitive Behavioural Therapy; BDI, Beck Depression Inventory; MADRS, Montgomery Asberg Depression Rating Scale; HADS, Hospital Anxiety and Depression Scale; CESD, Centre for Epidemiological Studies Depression Scale; PHQ-9, Patient Health Questionnaire 9-item; EDS, Edinburgh Depression Scale; MDI; Major Depression Inventory; QOL, Quality of Life Inventory; WSAS, Work and Social Adjustment Scale; SF-12(36), Short Form 12(36) Health Survey; WBQ, Well-Being Questionnaire; SDS, Sheehan Disability Schedule; WL, Waitlist; TAU, Treatment as Usual; LOCF, Last Observation Carry-forward; REML, Residual Maximum Likelihood Estimation; WOCF, Worst Observation Carry-forward; MI, Mean Imputation; LMM, Linear Mixed Modelling.