Is computerised CBT really helpful for adult depression?-A meta-analytic re-evaluation of CCBT for adult depression in terms of clinical implementation and methodological validity

So, Mirai; Yamaguchi, Sosei; Hashimoto, Sora; Sado, Mitsuhiro; Furukawa, Toshi A; McCrone, Paul

doi:10.1186/1471-244X-13-113

Table 1 Selected characteristics of randomised controlled studies examining the effect s of CCBT for adult depression

From: Is computerised CBT really helpful for adult depression?-A meta-analytic re-evaluation of CCBT for adult depression in terms of clinical implementation and methodological validity

First author and year of publication	Rrecruitent	Intervention, number of modules	N	Outcome measures	Function measures	Control group	F-U	Attrition rate (%)	Imputation	Country
Andersson (2005) [36]	community	guided iCBT, 5	117	BDI, MADRS	QOL	WL (online discussion group)	6 months	27%	LOCF	Sweden
Christensen (2004) [37]	community	unguided iCBT, 5	525	CES-D	na	Attention placebo	6 weeks	20%	LOCF	Australia
Clarke (2002) [38]	vio HMO	unguided iCBT, 7	299	CES-D	na	TAU	8 months	41%	unclear	USA
Clarke (2005)a	vio HMO	unguided iCBT, 7 + postcard-reminder	175	CES-D	SF-12	TAU	16 weeks	34%	REML	USA
Clarke (2005)b	vio HMO	unguided iCBT, 7 + telepone-reminder	180	CES-D	SF-12	TAU	16 weeks	34%	REML	USA
Clarke (2009) [39]	vio HMO	unguided iCBT, 4	160	PHQ-8	na	TAU	8 months	37%	REML	USA
de Graaf (2009) [40]	community	unguided iCBT, 8 or 9	303	BDI-ii	SF-36	TAU	6 months	5%	MI	the Netherlands
Meyer (2009) [41]	community	guided iCBT, 8	396	BDI	WSAS	WL	6 months	31%	replaced by pretreatment scores	German
Perini (2009) [42]	community	guided iCBT, 8	45	PHQ-9, BDI-ii	SDS	WL	8 weeks	27%	replaced by pretreatment scores	Australia
Ruwaard (2009) [43]	community	guided iCBT, 11Weeks	54	BDI	WBQ	WL	18 months	9%	WOCF	the Netherlands
Spek (2007) [44]	community	unguide iCBT, 8	301	BDI-ii, EDS	na	WL	2 weeks	40%	MI	the Netherlands
Titov (2009)a	community	technician-guided iCBT, 8	81	PHQ-9, BDI-ii	SDS	WL	16 weeks	8%	LOCF	Australia
Titov (2009)b	community	clinician-guided iCBT, 8	86	PHQ-9, BDI-ii	WBQ	WL	16 weeks	8%	LOCF	Australia
van Straten (2008) [45]	community	guided iCBT, 4	213	CESD, MDI	EuroQoL	WL	4 weeks	17%	MI	the Netherlands
Venrnmark (2010) [46]	community	guided iCBT, 8	88	BDI, MADRS	QOL	WL	6 months	14%	LOCF	Sweden
Warmerdam (2008) [47]	community	guided iCBT, 8	263	CESD	EuroQoL	WL	12 weeks	40%	LMM	the Netherlands

iCBT, Internet-based Cognitive Behavioural Therapy; cCBT, Computer-based Cognitive Behavioural Therapy; BDI, Beck Depression Inventory; MADRS, Montgomery Asberg Depression Rating Scale; HADS, Hospital Anxiety and Depression Scale; CESD, Centre for Epidemiological Studies Depression Scale; PHQ-9, Patient Health Questionnaire 9-item; EDS, Edinburgh Depression Scale; MDI; Major Depression Inventory; QOL, Quality of Life Inventory; WSAS, Work and Social Adjustment Scale; SF-12(36), Short Form 12(36) Health Survey; WBQ, Well-Being Questionnaire; SDS, Sheehan Disability Schedule; WL, Waitlist; TAU, Treatment as Usual; LOCF, Last Observation Carry-forward; REML, Residual Maximum Likelihood Estimation; WOCF, Worst Observation Carry-forward; MI, Mean Imputation; LMM, Linear Mixed Modelling.

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ISSN: 1471-244X

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