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Table 4 Multivariable logistic regression analyses using stepwise procedure

From: No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents

Model1
        B      SE       Wald       p value      OR 95% CI
G × E interaction −1.39 25254.67 0.000 1.000 0.25 0.000-
Genotype (G) −1.54 0.98 2.447 0.12 0.22 0.031-1.475
Adversity (E) 21.04 21970.77 0.000 1 1371627685 0.000-
Gender 23.7 6397.2 0.000 1 0.000 0.000-
Age 0.1 0.234 0.18 0.67 1.1 0.697-1.747
SES −1.64 0.77 0.000 1 1371627685 0.000-
FSIQ −0.79 0.39 4.057 0.04 0.92 0.855-0.998
Fit index of this model: χ2 = 61.216 (p < 0.001), -2log likelihood = 37.706, discriminate accuracy = 96.9%
Model2
        B      SE       Wald       p value      OR 95% CI
Genotype (G) −1.54 0.98 2.447 0.12 0.22 0.031-1.175
Adversity (E) 20.21 10910.59 0.000 1 599809518 0.000-
Gender −23.7 6393.91 0 1 0.000 0.000-
Age 0.1 0.23 0.18 0.67 1.1 0.697-1.747
SES −1.64 0.77 4.567 0.03 0.2 0.043-0.873
FSIQ −0.08 0.04 4.06 0.04 0.92 0.855-0.998
Fit index of this model: χ2 = 61.216 (p < 0.001), -2log likelihood = 37.706, discriminate accuracy = 96.9%
Model3
        B      SE       Wald       p value      OR 95% CI
Gender −22.31 7045.95 0 1 0 0.000
FSIQ −0.088 0.04 6.08 0.01 0.92 0.853-0.982
Fit index of this model: χ2 = 50.660 (p < 0.001), -2log likelihood = 48.262, discriminate accuracy = 96.9%
  1. note: B=unstandardized partial regression coefficient, SE = standard error, OR = odds ratio, Wald = (SE/B)2, CI = confidence interval.
  2. dependent variable is existence of diagnosis ( 0 = no, 1 = childhood depression).
  3. Independent variables: 5-HTTLPR genotype (0 = s/s, 1 = s/l, 2 = l/l), Adversity (maternal depression: 0 = no, 1 = yes). Gender (0 = female, 1 = male), SES(from 0 = low income to 5 = high income).