No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents

Table 4 Multivariable logistic regression analyses using stepwise procedure

Model1
	B	SE	Wald	p value	OR	95% CI
G × E interaction	−1.39	25254.67	0.000	1.000	0.25	0.000-
Genotype (G)	−1.54	0.98	2.447	0.12	0.22	0.031-1.475
Adversity (E)	21.04	21970.77	0.000	1	1371627685	0.000-
Gender	23.7	6397.2	0.000	1	0.000	0.000-
Age	0.1	0.234	0.18	0.67	1.1	0.697-1.747
SES	−1.64	0.77	0.000	1	1371627685	0.000-
FSIQ	−0.79	0.39	4.057	0.04	0.92	0.855-0.998
Fit index of this model: χ2 = 61.216 (p < 0.001), -2log likelihood = 37.706, discriminate accuracy = 96.9%
Model2
	B	SE	Wald	p value	OR	95% CI
Genotype (G)	−1.54	0.98	2.447	0.12	0.22	0.031-1.175
Adversity (E)	20.21	10910.59	0.000	1	599809518	0.000-
Gender	−23.7	6393.91	0	1	0.000	0.000-
Age	0.1	0.23	0.18	0.67	1.1	0.697-1.747
SES	−1.64	0.77	4.567	0.03	0.2	0.043-0.873
FSIQ	−0.08	0.04	4.06	0.04	0.92	0.855-0.998
Fit index of this model: χ2 = 61.216 (p < 0.001), -2log likelihood = 37.706, discriminate accuracy = 96.9%
Model3
	B	SE	Wald	p value	OR	95% CI
Gender	−22.31	7045.95	0	1	0	0.000
FSIQ	−0.088	0.04	6.08	0.01	0.92	0.853-0.982
Fit index of this model: χ2 = 50.660 (p < 0.001), -2log likelihood = 48.262, discriminate accuracy = 96.9%

note: B=unstandardized partial regression coefficient, SE = standard error, OR = odds ratio, Wald = (SE/B)2, CI = confidence interval.
dependent variable is existence of diagnosis ( 0 = no, 1 = childhood depression).
Independent variables: 5-HTTLPR genotype (0 = s/s, 1 = s/l, 2 = l/l), Adversity (maternal depression: 0 = no, 1 = yes). Gender (0 = female, 1 = male), SES(from 0 = low income to 5 = high income).

ISSN: 1471-244X