| |
Placebo
|
Olanzapine
|
|---|
| |
(N = 52)
|
(N = 104)
|
|---|
|
Female gender, n (%)
|
27 (51.9)
|
63 (60.6)
|
|
Age in years, mean (SD)
|
36.3 (9.5)
|
40.0 (11.0)
|
|
Age in years at onset of BD, mean (SD)
|
29.1 (8.8)
|
33.1 (10.9)
|
|
Prior episodes, mean (SD)
| | |
|
Manic
|
3.02 (3.07)
|
3.32 (4.46)
|
|
Depressive
|
3.77 (3.35)
|
4.54 (5.69)
|
|
Mixed
|
0.23 (0.70)
|
0.13 (0.48)
|
|
Weight in kg, mean (SD)
|
64.02 (12.14)
|
59.04 (12.35)
|
|
Illness severity scores, mean (SD)
| | |
|
MADRS total
|
28.62 (8.01)
|
29.00 (6.15)
|
|
YMRS total
|
0.85 (1.32)
|
0.88 (1.32)
|
|
HAMD-17 total
|
22.69 (4.08)
|
23.10 (3.78)
|
|
CGI-BP
| | |
|
Depression
|
4.23 (0.73)
|
4.35 (0.75)
|
|
Mania
|
1.02 (0.14)
|
1.03 (0.17)
|
|
Bipolar
|
4.10 (0.87)
|
4.17 (0.86)
|
- Abbreviations: BD = bipolar disorder; CGI-BP = Clinical Global Impressions-Bipolar Version Severity of Illness; HAMD-17 = Hamilton Depression Rating Scale-17 items; MADRS = Montgomery-Åsberg Depression Rating Scale; SD = standard deviation; YMRS = Young Mania Rating Scale.
