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Table 7 Holland et al., 1998

From: Antidepressants in the treatment of depression/depressive symptoms in cancer patients: a systematic review and meta-analysis

Domain

Description

Review author’s judgement

Sequence generation

Randomized study, randomization method not described.

“Unclear”

Allocation concealment

Method is not described.

“Unclear”

Blinding of participants, personnel, and outcome

Double blind study. More frequent anticholinergic effects in the fluoxetine group. Issue is not sufficiently addressed by the authors.

“Unclear”

Incomplete outcome data

The main outcome war the raw baseline to endpoint differences in HAM-D. There were 6 dropouts in the fluoxetine group, all due to AEs. There were 7 dropouts in the desipramine, 4 due to AEs, 3 to unknown reasons. Analysis according to ITT principle. Missing data imputation method: LOCF.

“No”

Selective outcome reporting

Study protocol is not available. All pre-specified outcomes are reported in the pre-specified way. No response criteria were defined. Improvement was not pre-specified.

“No”

Other sources of bias

The study seems to be free from other sources of bias.

“Yes”