Domain | Description | Review author’s judgement |
---|---|---|
Sequence generation | Randomized study, randomization method not described. | “Unclear” |
Allocation concealment | Method is not described. | “Unclear” |
Blinding of participants, personnel, and outcome | Double blind study. More frequent anticholinergic effects in the fluoxetine group. Issue is not sufficiently addressed by the authors. | “Unclear” |
Incomplete outcome data | The main outcome war the raw baseline to endpoint differences in HAM-D. There were 6 dropouts in the fluoxetine group, all due to AEs. There were 7 dropouts in the desipramine, 4 due to AEs, 3 to unknown reasons. Analysis according to ITT principle. Missing data imputation method: LOCF. | “No” |
Selective outcome reporting | Study protocol is not available. All pre-specified outcomes are reported in the pre-specified way. No response criteria were defined. Improvement was not pre-specified. | “No” |
Other sources of bias | The study seems to be free from other sources of bias. | “Yes” |