Table 2 Primary and secondary analyses, change from baseline to 2-hour timepoint (LOCF)
IM Olz, 10 mg (N=45) | IM Placebo (N=44) | pvalueb | |||||
|---|---|---|---|---|---|---|---|
Mean (points) | SD | 95%CI | Mean (points) | SD | 95%CI | ||
Baseline | |||||||
PANSS-EC total | 23.5 | 6.1 | 21.7, 25.4 | 23.3 | 4.9 | 21.8, 24.8 | .638 |
Poor impulse control | 4.8 | 1.2 | 4.5, 5.2 | 4.7 | 1.2 | 4.3, 5.0 | .336 |
Tension | 4.7 | 1.6 | 4.2, 5.2 | 4.7 | 1.1 | 4.3, 5.0 | .722 |
Hostility | 4.6 | 1.6 | 4.1, 5.1 | 4.6 | 1.3 | 4.2, 5.0 | .912 |
Uncooperativeness | 4.7 | 1.3 | 4.3, 5.1 | 4.8 | 1.2 | 4.4, 5.1 | .791 |
Excitement | 4.7 | 1.2 | 4.4, 5.1 | 4.6 | 1.0 | 4.3, 4.9 | .385 |
ACESa | 1.6 | 0.5 | 1.5, 1.7 | 1.6 | 0.5 | 1.5,1.8 | .741 |
2 hours | |||||||
PANSS-EC total | 14.3 | 6.0 | 12.5, 16.1 | 20.5 | 7.5 | 18.3, 22.8 | |
Poor impulse control | 3.0 | 1.3 | 2.6, 3.4 | 4.1 | 1.5 | 3.7, 4.6 | |
Tension | 2.9 | 1.2 | 2.5, 3.2 | 4.1 | 1.7 | 3.6, 4.6 | |
Hostility | 2.8 | 1.3 | 2.4, 3.1 | 4.0 | 1.7 | 3.5, 4.5 | |
Uncooperativeness | 2.9 | 1.4 | 2.5, 3.3 | 4.3 | 1.6 | 3.8, 4.8 | |
Excitement | 2.8 | 1.2 | 2.4, 3.2 | 4.0 | 1.5 | 3.5, 4.4 | |
ACES | 3.5 | 1.7 | 2.9, 4.0 | 2.2 | 1.3 | 1.8, 2.6 | |
Change, baseline-2 hours | |||||||
PANSS-EC Total | −9.2 | 4.5 | −10.6, -7.9 | −2.8 | 5.6 | −4.5, -1.1 | <.001 |
Poor impulse control | −1.9 | 1.0 | −2.2, -1.6 | −0.6 | 1.2 | −0.9, -0.2 | <.001 |
Tension | −1.8 | 1.1 | −2.2, -1.5 | −0.6 | 1.1 | −0.9, -0.2 | <.001 |
Hostility | −1.8 | 1.2 | −2.2, -1.5 | −0.6 | 1.5 | −1.0, -0.1 | <.001 |
Uncooperativeness | −1.7 | 0.9 | −2.0, -1.5 | −0.5 | 1.2 | −0.8, -0.1 | <.001 |
Excitement | −1.9 | 1.1 | −2.3, -1.6 | −0.6 | 1.4 | −1.0, -0.2 | <.001 |
ACES | 1.9 | 1.5 | 1.4, 2.3 | 0.6 | 1.1 | 0.2, 0.9 | <.001 |