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Table 3 Definition of treatment adherence in the CBT and sertraline treatment groups

From: Study protocol of the Diabetes and Depression Study (DAD): a multi-center randomized controlled trial to compare the efficacy of a diabetes-specific cognitive behavioral group therapy versus sertraline in patients with major depression and poorly controlled diabetes mellitus

Adherence categories CBT Sertraline (randomized sample) Sertraline (ITT sample)
Adherent Participation in ≥ 8 sessions of CBT 2 measures SER and corresponding ratio DSER:SER in target range ≥ 5 measures SER and corresponding ratio DSER:SER in target range
Partially non-adherent Participation in 1–7 sessions of CBT 1 measures SER and corresponding ratio DSER:SER in target range 1-4 measures SER and corresponding ratio DSER:SER in target range
Non-adherent No participation in any session of CBT no measures SER and corresponding ratio DSER:SER in target range no measures SER and corresponding ratio DSER:SER in target range
  1. Note: SER: blood concentration of sertraline. DSER:SER: ratio of desmethylsertraline to sertraline concentrations. Target ranges of SER were defined as concentrations between 10–100 ng/ml [55]. Target ranges of DSER:SER were defined as 0.85–4.25, corresponding to the mean ± 2 standard deviations (M = 2.55, SD = 0.85) derived from 348 samples by Reis et al. [51].
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BMC Psychiatry

ISSN: 1471-244X

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