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Table 1 Studies of guideline concordance in bipolar disorder

From: Pharmacotherapy for bipolar disorder and concordance with treatment guidelines: survey of a general population sample referred to a tertiary care service

  Population N Guidelines % Concordance
Unutzer et al. 2000 [30] Out-patients 1246 BD Expert consensus panel 83%
Lim et al. 2001 [24] In-patients 1421 BDI Expert consensus panel Manic with psychotic features: 38% without: 16%; Depressive with psychotic features: 31%; without: 17%
Simon et al. 2004 [31] Out-patients 665 BDI + 239 BDII Several guidelines BDI: 65.4% BDII: 52.7%
Kilbourne et al. 2005 [32] In- and out-patients 2316 BDI APA and Department of Veterans Affairs Bipolar specific MS: 74.6% Any MS or neuroleptics second generation: 84.4%
Farrelly et al. 2006 [33] Out-patients 224 mood episodes in 84 BD I and II British Association for Psychopharmacology Manic: 81% Depressive: 64% Mixed: 62%
Dennehy et al. 2007 [29] Out-patients 469 BDI 198 BDII Several guidelines Depressive: 83.4% Hypomanic/manic: 81.9% Mixed: 81.8%
Bush et al. 2007 [34] In- and out-patients 2644 BDI Several guidelines 67%
Arvilommi et al. 2007 [25] In- and out-patients BDI – 90 BDII- 101 Several guidelines BDI: 55.6% BDII: 30.7%
Smith et al. 2008 [27] In-patients 23 BD Expert consensus panel 52% in naturalistic settings, increased to 75% after intervention
Bauer et al. 2009 [28]   306 (87% BDI) Department of Veterans Affairs 50%-60% at index hospitalization in collaborative model; declined to 30%-40% after two years
Altinbas et al. 2011 [26] Out-patients 263 depressive episodes in 142 patients (131 BDI) Turkish Psychiatric Association Guidelines for Bipolar Disorder Severity of the episode: Mild: 29.%; Moderate or severe without psychosis: 27.4%; severe with psychos: 87.5%
  1. BD Bipolar Disorder, BDI Bipolar Disorder type I, BDII Bipolar Disorder type II, MS Mood Stabilizer, APA American Psychiatric Association.