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Table 1 Genome-wide gene expression studies of bipolar disorder with brain tissue samples included in the mega-analysis

From: Systematic review of genome-wide gene expression studies of bipolar disorder

Study

Disorder

Source of samples

BP

CTRL

Brain region/RNA source

Genome-wide array platform

Total probesets

Probesets after P/A filter

After gene mapping

Included in mega-analysis

Any brain region

Prefrontal cortex

Hippocampus

a Altar A. et al.

BP, SCZ

SMRI(A)

32

34

FrontalBA46

hgu133a

22283

15023

8962

YES

YES

-

Bahn et al.

BP

SMRI(A)

32

33

FrontalBA46

hgu133a

22283

15595

9214

YES

YES

-

b T. Kato et al.

BP, SCZ

SMRI(A)

33

34

FrontalBA46

hgu133a

22283

15972

9418

YES

YES

-

c Dobrin et al.

BP, SCZ

SMRI(A)

27

25

FrontalBA46

hgu133p

54675

40605

15995

YES

YES

-

Laeng et al.

BP, SCZ

SMRI(A)

20

21

Hippocampus CA1

hgu133p

54675

29854

13459

YES

-

YES

Chen et al.

BP, SCZ

SMRI(C)

14

13

FrontalBA46

hgu133p

54675

29854

12864

YES

YES

-

d Kemether et al.

BP, MD, SCZ

SMRI(C)

11

12

Thalamus MD

hgu133p

54675

30201

13464

YES

-

-

Harvard_collection

BP, SCZ

HBTRC

19

26

Frontal McL66

hgu133a

22283

15105

9021

YES

YES

-

Harvard_collection

BP, SCZ

HBTRC

15

21

Cingulate Cortex

hgu133a

22283

15264

8993

YES

-

-

Harvard_collection

BP, SCZ

HBTRC

8

10

Hippocampus

hgu95av2

12625

no filter

8438

-

-

YES

  1. Number of outlier samples excluded from each study, a = 5, b = 2, c = 8, d = 1.
  2. HBTRC – Harvard Brain Tissue Resource Center (McLean Hospital, Belmont, Massachusetts).
  3. SMRI (A/C) - Stanley Medical Research Institute/Stanley Foundation (Array Collection/Neuropathology Collection).