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Table 1 Genome-wide gene expression studies of bipolar disorder with brain tissue samples included in the mega-analysis

From: Systematic review of genome-wide gene expression studies of bipolar disorder

Study Disorder Source of samples BP CTRL Brain region/RNA source Genome-wide array platform Total probesets Probesets after P/A filter After gene mapping Included in mega-analysis
Any brain region Prefrontal cortex Hippocampus
a Altar A. et al. BP, SCZ SMRI(A) 32 34 FrontalBA46 hgu133a 22283 15023 8962 YES YES -
Bahn et al. BP SMRI(A) 32 33 FrontalBA46 hgu133a 22283 15595 9214 YES YES -
b T. Kato et al. BP, SCZ SMRI(A) 33 34 FrontalBA46 hgu133a 22283 15972 9418 YES YES -
c Dobrin et al. BP, SCZ SMRI(A) 27 25 FrontalBA46 hgu133p 54675 40605 15995 YES YES -
Laeng et al. BP, SCZ SMRI(A) 20 21 Hippocampus CA1 hgu133p 54675 29854 13459 YES - YES
Chen et al. BP, SCZ SMRI(C) 14 13 FrontalBA46 hgu133p 54675 29854 12864 YES YES -
d Kemether et al. BP, MD, SCZ SMRI(C) 11 12 Thalamus MD hgu133p 54675 30201 13464 YES - -
Harvard_collection BP, SCZ HBTRC 19 26 Frontal McL66 hgu133a 22283 15105 9021 YES YES -
Harvard_collection BP, SCZ HBTRC 15 21 Cingulate Cortex hgu133a 22283 15264 8993 YES - -
Harvard_collection BP, SCZ HBTRC 8 10 Hippocampus hgu95av2 12625 no filter 8438 - - YES
  1. Number of outlier samples excluded from each study, a = 5, b = 2, c = 8, d = 1.
  2. HBTRC – Harvard Brain Tissue Resource Center (McLean Hospital, Belmont, Massachusetts).
  3. SMRI (A/C) - Stanley Medical Research Institute/Stanley Foundation (Array Collection/Neuropathology Collection).