Table 5 Severely impaired interpretation performers (LIP) show a more severe psychopathology, compromised cognition and emotional processing compared to high interpretation performers (HIP)

Disease relevant confounders

Years of education

median

12.0

11.0

13.0

−1.55

5.4 x10 ^-4

(years)

interquartile

[10.0, 13.5]

[9.0,13.0]

[10.0,15.0]

[−2.42, -0.68]

(t₁₇₄=−3.525 ^a)

range

(8.0-27.0)

(8.0-20.5)

(8.0-24.0)

Duration of disease

median

11.0

13.7

11.1

0.28

(years)

interquartile

[4.7, 20.1]

[6.4, 21.9]

[5.3, 20.9]

-

(W=3466^b)

range

(0.008,58.4)

(0.1, 47.4)

(0.6, 45.3)

Number of

median

3.0

3.0

4.0

0.10

hospitalizations

interquartile

[2.0, 6.0]

[2.0, 5.0]

[3.0, 6.0]

-

(W=2532^b)

range

(0, 55)

(1, 44)

(1, 50)

Chlorpromazine

median

500

600

450

0.068

equivalents

interquartile

[250, 900]

[300, 1072]

[228, 817]

-

(W=3216^b)

range

(0, 7375)

(0, 3238)

(0, 3064)

Functional outcome, disease severity and psychopathology

General assessment of

mean ± SD

45.6 ± 17.2

38.0 ± 17.1

49.8 ± 17.0

−11.93

6.5x10 ^-6

functioning (GAF)

range

(5, 90)

(10, 85)

(20, 90)

[−16.99, -6.87]

(t₁₇₁=−4.654^a)

Age-at-prodrome (years)

median

20

19

23

−2.70

0.054

interquartile

[17,26]

[16,24]

[17,30]

[−5.44, 0.05]

(t₁₅₃=−1.942^a)

range

(2, 66)

(12, 66)

(2, 47)

PANSS negative

median

17.0

22.0

15.0

4.54

1.7 x10 ^-4

interquartile

[12.0, 23.0]

[14.0, 27.0]

[11.0, 21.8]

[2.21, 6.88]

(t₁₇₁= 3.840^a)

range

(7.0, 44.0)

(7.0, 40.0)

(7.0, 38.0)

PANSS positive

median

12.0

15.0

11.0

3.96

1.6 x10 ^-4

interquartile

[9.0, 17.0]

[10.0, 22.0]

[8.0, 15.8]

[1.94, 5.98]

(t₁₇₁= 3.869^a)

range

(7.0, 38.0)

(7.0, 37.0)

(7.0, 38.0)

Disease-related cognition

Higher cognition

mean ± SD

−0.03 ± 0.78

−0.41 ± 0.84

0.07 ± 0.83

−0.24

4.3 x10 ^-3

composite^c

range

(−2.64, 1.93)

(−2.64, 1.40)

(−1.92, 1.77)

[−0.40, -0.07]

(t₁₆₉=−2.896^a)

Alertness (TAP)^c

median

−282

−331

−270

−80.75

1.4 x10 ^-4

(msec)

interquartile

[−350, -245]

[−479, -270]

[−311, -237]

[−121.61, -39.89]

(t₁₆₄=−3.902^a)

range

(−1288, -163)

(−1219, -206)

(−878, -192)

Emotional processing items

PANSS negative

median

8.0

10.0

7.0

3.3 x10 ^-3

N1+N2+N3^d

interquartile

[5.0, 11.0]

[6.0, 12.3]

[4.0, 11.0]

-

(W=2883^b)

range

(0.0, 21.0)

(3.0, 18.0)

(0.0, 16.0)