| | |
Descriptive
| |
LIP compared to HIP
|
|---|
|
SZ (N=881)
|
LIP (N=88)
|
HIP (N=88)
|
Effect [95%CI]
|
P (Statistic)
|
|---|
|
Disease relevant confounders
|
|
Years of education
|
median
|
12.0
|
11.0
|
13.0
|
−1.55
|
5.4 x10
-4
|
|
(years)
|
interquartile
|
[10.0, 13.5]
|
[9.0,13.0]
|
[10.0,15.0]
|
[−2.42, -0.68]
|
(t174=−3.525 a)
|
| |
range
|
(8.0-27.0)
|
(8.0-20.5)
|
(8.0-24.0)
| | |
|
Duration of disease
|
median
|
11.0
|
13.7
|
11.1
| |
0.28
|
|
(years)
|
interquartile
|
[4.7, 20.1]
|
[6.4, 21.9]
|
[5.3, 20.9]
|
-
|
(W=3466b)
|
| |
range
|
(0.008,58.4)
|
(0.1, 47.4)
|
(0.6, 45.3)
| | |
|
Number of
|
median
|
3.0
|
3.0
|
4.0
| |
0.10
|
|
hospitalizations
|
interquartile
|
[2.0, 6.0]
|
[2.0, 5.0]
|
[3.0, 6.0]
|
-
|
(W=2532b)
|
| |
range
|
(0, 55)
|
(1, 44)
|
(1, 50)
| | |
|
Chlorpromazine
|
median
|
500
|
600
|
450
| |
0.068
|
|
equivalents
|
interquartile
|
[250, 900]
|
[300, 1072]
|
[228, 817]
|
-
|
(W=3216b)
|
| |
range
|
(0, 7375)
|
(0, 3238)
|
(0, 3064)
| | |
|
Functional outcome, disease severity and psychopathology
|
|
General assessment of
|
mean ± SD
|
45.6 ± 17.2
|
38.0 ± 17.1
|
49.8 ± 17.0
|
−11.93
|
6.5x10
-6
|
|
functioning (GAF)
|
range
|
(5, 90)
|
(10, 85)
|
(20, 90)
|
[−16.99, -6.87]
|
(t171=−4.654a)
|
|
Age-at-prodrome (years)
|
median
|
20
|
19
|
23
|
−2.70
|
0.054
|
|
interquartile
|
[17,26]
|
[16,24]
|
[17,30]
|
[−5.44, 0.05]
|
(t153=−1.942a)
|
|
range
|
(2, 66)
|
(12, 66)
|
(2, 47)
| | |
|
PANSS negative
|
median
|
17.0
|
22.0
|
15.0
|
4.54
|
1.7 x10
-4
|
|
interquartile
|
[12.0, 23.0]
|
[14.0, 27.0]
|
[11.0, 21.8]
|
[2.21, 6.88]
|
(t171= 3.840a)
|
|
range
|
(7.0, 44.0)
|
(7.0, 40.0)
|
(7.0, 38.0)
| | |
|
PANSS positive
|
median
|
12.0
|
15.0
|
11.0
|
3.96
|
1.6 x10
-4
|
|
interquartile
|
[9.0, 17.0]
|
[10.0, 22.0]
|
[8.0, 15.8]
|
[1.94, 5.98]
|
(t171= 3.869a)
|
|
range
|
(7.0, 38.0)
|
(7.0, 37.0)
|
(7.0, 38.0)
| | |
|
Disease-related cognition
|
|
Higher cognition
|
mean ± SD
|
−0.03 ± 0.78
|
−0.41 ± 0.84
|
0.07 ± 0.83
|
−0.24
|
4.3 x10
-3
|
|
compositec
|
range
|
(−2.64, 1.93)
|
(−2.64, 1.40)
|
(−1.92, 1.77)
|
[−0.40, -0.07]
|
(t169=−2.896a)
|
|
Alertness (TAP)c
|
median
|
−282
|
−331
|
−270
|
−80.75
|
1.4 x10
-4
|
|
(msec)
|
interquartile
|
[−350, -245]
|
[−479, -270]
|
[−311, -237]
|
[−121.61, -39.89]
|
(t164=−3.902a)
|
| |
range
|
(−1288, -163)
|
(−1219, -206)
|
(−878, -192)
| | |
|
Emotional processing items
|
|
PANSS negative
|
median
|
8.0
|
10.0
|
7.0
| |
3.3 x10
-3
|
|
N1+N2+N3d
|
interquartile
|
[5.0, 11.0]
|
[6.0, 12.3]
|
[4.0, 11.0]
|
-
|
(W=2883b)
|
| |
range
|
(0.0, 21.0)
|
(3.0, 18.0)
|
(0.0, 16.0)
| | |
- Multiple testing adjusted significances (Bonferroni: p≤0.0045) are set in boldfaces, all other p-values≤0.05 in italic. at-Statistic tdf with df degrees of freedom for estimation of difference in means (employing a linear model on Blom-transformed trait; small differences in degrees of freedom are due to low percentages of missing trait values). bWilcoxon rank sum test. cAdjusted for age and PANSS negative. dN1: Blunted affect, N2: Emotional withdrawal, N3: Poor rapport. Abbreviations: SZ= Descriptive statistics for whole schizophrenia sample (N=881); HIP= High interpretation performers (N=88); LIP= Low interpretation performers (N=88), OR=Odds Ratio.
