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Table 4 Fixed effects slopes for individual symptoms

From: Time-course of the DSM-5 cannabis withdrawal symptoms in poly-substance abusers

   Linear    Quadratic    
Symptom:   Beta SE F-test (1,145) Beta SE F-test (2,144) Additional substances
Irritability/anger Linear 0.001 0.001 0.03 0.089 0.03 *4.53  
  Squared     -0.003 0.001   
Nervousness Linear -0.024 0.008 **9.18 0.025 0.030 **6.08  
  Squared     -0.014 0.008   
Insomnia Linear -0.036 0.008 ***18.76 -0.042 0.031 ***9.34 Stimulants +
  Squared     0.000 0.000   
Loss of appetite Linear -0.006 0.006 1.01 -0.029 0.022 1.09 Opioids -
  Squared     0.001 0.001   
I am restless Linear -0.024 0.008 **9.66 0.009 0.029 **5.54  
  Squared     -0.001 0.001   
I feel depressed Linear -0.016 0.007 *5.37 -0.014 0.027 2.67  
  Squared     -0.000 0.001   
Physical symptoms Linear -0.015 0.007 *4.73 -0.034 0.027 2.61  
  Squared     0.001 0.001   
Vivid dreams Linear 0.017 0.009 3.35 0.114 0.033 **6.30  
  Squared     -0.003 0.001   
  1. All effects controlled for three additional substances (all time-variant variables): Days since last alcohol or benzodiazepine use; Days since last opioid use; Days since last CS use.
  2. Coefficients in bold are significant at p < 0.01, coefficients in italics are significant at p < 0.05.
  3. F-tests for linear model test that the linear effect of time since last use of cannabis is significant. F-tests for quadratic models test that the combined effect of the linear and the squared effect of days since last use of cannabis is significant. * p < 0.05. ** p < 0.01. *** p < 0.001.