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Table 2 Mean scores (SD) for the cognitive tests in patients at 6 months after acute episode and in healthy control subjects

From: Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis

Cognitive task

Controls

Patients

Confidence

t*

Pvalue

 

(n = 45)

(n = 45)

interval

  

Memory and learning

     

Immediate Logical memory

10.50 (2.81)

8.05 (3.06)

0.622-0.896

3.635

0.001*

Learning Curve

11.39 (2.76)

10.66 (2.90)

0.772-1.072

1.134

0.260

Immediate Verbal Paired Associates

10.84 (3.80)

7.68 (3.22)

0.679-0.904

3.860

<0.001*

Delayed Logical memory

10.74 (3.45)

7.87 (3.48)

0.671-0.912

3.610

0.001*

Delayed Verbal Paired Associates

9.87 (2.04)

8.26 (2.43)

0.577-0.907

3.114

0.003*

Executive function/Working memory

     

Trail Making B

62.33 (23.36)

95.27 (42.87)

1.016-1.053

−4.525

<0.001*

WAIS-III Letter-Number Span

11.22 (3.42)

8.02 (2.99)

0.616-0.856

4.695

<0.001*

WAIS-III Digits

10.38 (3.06)

8.89 (2.60)

0.710-0.968

2.488

0.015

WCST Number of errors

102.93 (16.51)

86.20 (22.64)

0.936-0.982

3.975

<0.001*

WCST Perseverative errors

102.93 (16.51)

89.50 (27.82)

0.959-0.994

2.745

0.007

WCST% Conceptual level R

102.88 (15.73)

86.14 (22.64)

0.938-0.984

3.683

<0.001*

Number of words FAS

14.16 (3.51)

12.44 (4.62)

0.810-1.002

1.988

0.05

Category fluency (animals)

22.69 (5.83)

18.16 (5.69)

0.795-0.945

3.729

<0.001*

Stroop interference

54.80 (8.09)

50.36 (8.05)

0.875-0.987

2.596

0.011

Processing speed and attention

     

Trail Making A

35.00 (16.51)

47.29 (17.45)

1.016-1.079

−3.432

0.001*

WAIS-III Digit-Symbol Coding

10.24 (3.72)

7.52 (3.45)

0.698-0.932

3.282

0.002*

Stroop words

49.95 (7.59)

44.47 (9.49)

0.873-0.978

3.008

0.003*

Stroop colours

45.77 (6.67)

39.40 (8.62)

0.841-0.955

3.894

<0.001*

Intelligence

     

WAIS-III Vocabulary

10.95 (2.19)

9.15 (3.02)

0.633-0.920

3.134

0.002*

WAIS-III Similarities

10.76 (2.36)

8.55 (2.48)

0.547-0.850

3.978

<0.001*

  1. * Student’s t-test statistic.
  2. Standard ranges: memory and learning: low ≤ 7, normal = 8-12, high ≥ 13; WAIS-III: low ≤ 7, normal = 8-12, high ≥ 13; Stroop: low ≤ 39, normal = 40-60, high ≥ 61; WCST (Wisconsin Card Sorting Test): deterioration < 106; no deterioration > 107; Trail Making A: low ≤ 39; normal ≥ 40; Trail Making B: low ≤ 91; normal ≥ 92; FAS (Fluency Assessment Scale): low ≤ 9; normal ≥ 10.