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Table 5 Significant associations of depression severity and gene expression for HRSD and QIDS controlling for BPD vs. MDD diagnosis, age, and medication use

From: Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

GENE QIDSt p value η2 HRSDt p value η2
P2RX1 2.86 0.011 0.296 2.44 0.026 0.236
P2RY1 3.12 0.006 0.333 2.10 0.051 0.189
TRPV4 2.29 0.035 0.234 −0.14 0.893 0.001
IL10 2.28 0.036 0.227 −0.35 0.734 0.007
  1. Depression severity assessed by QIDS or HRSD using 5 factor regression model with inclusion of diagnosis, age, anticonvulsant use, and antidepressant/antipsychotic use. Model has 23 patients, 5 variables, results in 17 degrees of freedom.
  2. p value is for effect of depression severity after adjusting for the effects of the other 4 factors.
  3. Effect sizes using η2 for where depression severity was significant in the regression model were large (>0.14) for the 4 genes using QIDS and for P2RX1 and P2RY1 using HRSD.
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