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Table 3 Association of HPS4 SNPs with cognitive domains measured by the BACS-J in patients with schizophrenia

From: Association of the Hermansky–Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects

Cognitive domain SNP   Dominant model Recessive model Additive model
   β t P(perm) β t P(perm) β t P(perm)
Verbal memory rs4822724 -0.028 -0.296 0.999 -0.031 -0.323 0.998 -0.023 -0.388 0.991
  rs61276843 0.183 2.062 0.165 0.275 1.120 0.757 0.164 2.139 0.131
  rs9608491 -0.040 -0.489 0.989 0.147 0.644 0.967 -0.016 -0.226 0.999
  rs713998 0.210 2.704 0.029 0.097 0.644 0.967 0.146 2.386 0.074
  rs2014410 -0.128 -1.651 0.360 -0.236 -1.388 0.569 -0.123 -1.912 0.212
Working memory rs4822724 0.183 1.882 0.243 -0.026 -0.255 1.000 0.065 1.037 0.746
  rs61276843 0.024 0.259 1.000 -0.123 -0.474 0.992 0.006 0.076 1.000
  rs9608491 0.117 1.370 0.554 0.254 1.063 0.797 0.115 1.535 0.406
  rs713998 0.068 0.824 0.896 -0.091 -0.580 0.982 0.026 0.408 0.988
  rs2014410 -0.012 -0.141 1.000 -0.313 -1.753 0.329 -0.053 -0.781 0.888
Motor speed rs4822724 0.043 0.356 0.997 0.110 0.883 0.887 0.059 0.770 0.895
  rs61276843 -0.079 -0.685 0.951 0.038 0.118 1.000 -0.056 -0.555 0.969
  rs9608491 0.193 1.830 0.260 0.290 0.983 0.838 0.177 1.912 0.215
  rs713998 -0.081 -0.797 0.910 0.093 0.476 0.992 -0.035 -0.430 0.988
  rs2014410 0.069 0.683 0.952 -0.169 -0.763 0.936 0.024 0.280 0.998
Verbal fluency rs4822724 -0.087 -0.680 0.947 -0.036 -0.272 1.000 -0.049 -0.601 0.956
  rs61276843 0.061 0.500 0.987 -0.066 -0.196 1.000 0.039 0.371 0.993
  rs9608491 0.047 0.421 0.993 0.026 0.083 1.000 0.039 0.394 0.991
  rs713998 0.152 1.412 0.524 0.210 1.016 0.820 0.129 1.530 0.419
  rs2014410 -0.050 -0.473 0.989 -0.102 -0.432 0.995 -0.050 -0.559 0.966
Attention rs4822724 -0.075 -0.917 0.855 0.016 0.181 1.000 -0.025 -0.473 0.982
  rs61276843 0.065 0.815 0.903 0.099 0.453 0.994 0.058 0.847 0.858
  rs9608491 0.045 0.625 0.965 0.094 0.464 0.993 0.044 0.692 0.924
  rs713998 0.123 1.778 0.294 0.125 0.937 0.870 0.097 1.785 0.265
  rs2014410 -0.051 -0.738 0.932 -0.132 -0.871 0.897 -0.055 -0.948 0.803
Executive function rs4822724 -0.132 -1.096 0.740 -0.132 -1.057 0.798 -0.104 -1.352 0.522
  rs61276843 0.257 2.242 0.111 -0.373 -1.169 0.730 0.156 1.561 0.390
  rs9608491 -0.054 -0.511 0.985 -0.150 -0.506 0.991 -0.056 -0.606 0.953
  rs713998 0.319 3.191 0.0073* -0.050 -0.259 1.000 0.188 2.377 0.080
  rs2014410 -0.101 -1.002 0.797 -0.251 -1.133 0.752 -0.107 -1.269 0.578
  1. Linear regression analyses were performed with the covariates of age, sex, education years, and JART scores. Permutation P-values, P (perm), were adjusted for multiple testing between SNPs by each BACS-J subtest P-values < 0.0083 (0.05/6) were considered as statistically significant to correct for the number of BACS-J subtests. P-values < 0.05 are in bold, and statistically significant results are marked with ‘*’.
  2. BACS-J: Brief Assessment of Cognition in Schizophrenia, Japanese-language version.