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Table 4 Association of HPS4 SNPs with cognitive domains measured by the BACS-J in healthy controls

From: Association of the Hermansky–Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects

Cognitive domain SNP Dominant model Recessive model Additive model
   β t P(perm) β t P(perm) β t P(perm)
Verbal memory rs4822724 0.075 0.870 0.873 0.147 1.670 0.380 0.081 1.539 0.402
  rs61276843 -0.071 -0.777 0.913 -0.072 -0.208 1.000 -0.065 -0.767 0.890
  rs9608491 0.029 0.352 0.997 0.303 1.798 0.304 0.064 0.975 0.778
  rs713998 -0.134 -1.724 0.317 -0.124 -0.675 0.967 -0.111 -1.700 0.310
  rs2014410 0.014 0.182 1.000 0.010 0.085 1.000 0.009 0.169 1.000
Working memory rs4822724 0.225 2.412 0.069 0.174 1.793 0.313 0.148 2.574 0.047
  rs61276843 -0.150 -1.494 0.459 -0.882 -2.361 0.086 -0.181 -1.961 0.193
  rs9608491 0.162 1.797 0.283 0.701 3.875 0.001* 0.209 2.934 0.017
  rs713998 -0.187 -2.202 0.120 -0.646 -3.276 0.0065* -0.217 -3.050 0.011
  rs2014410 -0.069 -0.824 0.893 0.096 0.747 0.945 -0.014 -0.236 0.999
Motor speed rs4822724 0.085 0.764 0.921 0.342 3.027 0.013 0.155 2.274 0.095
  rs61276843 -0.179 -1.502 0.458 -0.280 -0.626 0.973 -0.169 -1.539 0.399
  rs9608491 0.045 0.417 0.994 0.159 0.722 0.951 0.052 0.613 0.951
  rs713998 -0.127 -1.259 0.627 -0.271 -1.139 0.749 -0.126 -1.475 0.439
  rs2014410 -0.090 -0.897 0.863 -0.075 -0.495 0.992 -0.062 -0.869 0.844
Verbal fluency rs4822724 -0.048 -0.487 0.989 0.051 0.500 0.991 -7.1 × 10-5 -0.001 1.000
  rs61276843 -0.217 -2.084 0.168 -0.574 -1.469 0.522 -0.219 -2.287 0.092
  rs9608491 -0.149 -1.594 0.402 0.062 0.321 1.000 -0.086 -1.145 0.664
  rs713998 -0.171 -1.935 0.221 -0.160 -0.763 0.942 -0.143 -1.911 0.213
  rs2014410 0.174 1.993 0.199 0.051 0.379 0.998 0.099 1.590 0.373
Attention rs4822724 0.090 1.171 0.697 0.063 0.793 0.929 0.057 1.199 0.629
  rs61276843 -0.141 -1.718 0.326 -0.359 -1.168 0.728 -0.141 -1.873 0.226
  rs9608491 0.062 0.842 0.892 0.229 1.508 0.481 0.074 1.257 0.585
  rs713998 -0.044 -0.629 0.962 -0.226 -1.378 0.575 -0.060 -1.026 0.744
  rs2014410 -0.008 -0.116 1.000 -0.035 -0.335 0.998 -0.004 -0.074 1.000
Executive function rs4822724 0.003 0.032 1.000 0.039 0.381 0.997 0.015 0.248 0.998
  rs61276843 -0.049 -0.468 0.987 0.183 0.464 0.993 -0.031 -0.316 0.996
  rs9608491 0.003 0.035 1.000 -0.066 -0.339 0.998 -0.008 -0.104 1.000
  rs713998 0.020 0.229 1.000 0.099 0.470 0.993 0.027 0.363 0.993
  rs2014410 -0.049 -0.558 0.976 -0.057 -0.423 0.996 -0.037 -0.594 0.954
  1. Linear regression analyses were performed with the covariates of age, sex, education years, and JART scores. Permutation P-values, P (perm), were adjusted for multiple testing between SNPs by each BACS-J subtest P-values < 0.0083 (0.05/6) were considered as statistically significant to correct for the number of BACS-J subtests. P-values < 0.05 are in bold, and statistically significant results are marked with ‘*’.
  2. BACS-J: Brief Assessment of Cognition in Schizophrenia, Japanese-language version.