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Table 4 Association of HPS4 SNPs with cognitive domains measured by the BACS-J in healthy controls

From: Association of the Hermansky–Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects

Cognitive domain

SNP

Dominant model

Recessive model

Additive model

  

β

t

P(perm)

β

t

P(perm)

β

t

P(perm)

Verbal memory

rs4822724

0.075

0.870

0.873

0.147

1.670

0.380

0.081

1.539

0.402

 

rs61276843

-0.071

-0.777

0.913

-0.072

-0.208

1.000

-0.065

-0.767

0.890

 

rs9608491

0.029

0.352

0.997

0.303

1.798

0.304

0.064

0.975

0.778

 

rs713998

-0.134

-1.724

0.317

-0.124

-0.675

0.967

-0.111

-1.700

0.310

 

rs2014410

0.014

0.182

1.000

0.010

0.085

1.000

0.009

0.169

1.000

Working memory

rs4822724

0.225

2.412

0.069

0.174

1.793

0.313

0.148

2.574

0.047

 

rs61276843

-0.150

-1.494

0.459

-0.882

-2.361

0.086

-0.181

-1.961

0.193

 

rs9608491

0.162

1.797

0.283

0.701

3.875

0.001*

0.209

2.934

0.017

 

rs713998

-0.187

-2.202

0.120

-0.646

-3.276

0.0065*

-0.217

-3.050

0.011

 

rs2014410

-0.069

-0.824

0.893

0.096

0.747

0.945

-0.014

-0.236

0.999

Motor speed

rs4822724

0.085

0.764

0.921

0.342

3.027

0.013

0.155

2.274

0.095

 

rs61276843

-0.179

-1.502

0.458

-0.280

-0.626

0.973

-0.169

-1.539

0.399

 

rs9608491

0.045

0.417

0.994

0.159

0.722

0.951

0.052

0.613

0.951

 

rs713998

-0.127

-1.259

0.627

-0.271

-1.139

0.749

-0.126

-1.475

0.439

 

rs2014410

-0.090

-0.897

0.863

-0.075

-0.495

0.992

-0.062

-0.869

0.844

Verbal fluency

rs4822724

-0.048

-0.487

0.989

0.051

0.500

0.991

-7.1 × 10-5

-0.001

1.000

 

rs61276843

-0.217

-2.084

0.168

-0.574

-1.469

0.522

-0.219

-2.287

0.092

 

rs9608491

-0.149

-1.594

0.402

0.062

0.321

1.000

-0.086

-1.145

0.664

 

rs713998

-0.171

-1.935

0.221

-0.160

-0.763

0.942

-0.143

-1.911

0.213

 

rs2014410

0.174

1.993

0.199

0.051

0.379

0.998

0.099

1.590

0.373

Attention

rs4822724

0.090

1.171

0.697

0.063

0.793

0.929

0.057

1.199

0.629

 

rs61276843

-0.141

-1.718

0.326

-0.359

-1.168

0.728

-0.141

-1.873

0.226

 

rs9608491

0.062

0.842

0.892

0.229

1.508

0.481

0.074

1.257

0.585

 

rs713998

-0.044

-0.629

0.962

-0.226

-1.378

0.575

-0.060

-1.026

0.744

 

rs2014410

-0.008

-0.116

1.000

-0.035

-0.335

0.998

-0.004

-0.074

1.000

Executive function

rs4822724

0.003

0.032

1.000

0.039

0.381

0.997

0.015

0.248

0.998

 

rs61276843

-0.049

-0.468

0.987

0.183

0.464

0.993

-0.031

-0.316

0.996

 

rs9608491

0.003

0.035

1.000

-0.066

-0.339

0.998

-0.008

-0.104

1.000

 

rs713998

0.020

0.229

1.000

0.099

0.470

0.993

0.027

0.363

0.993

 

rs2014410

-0.049

-0.558

0.976

-0.057

-0.423

0.996

-0.037

-0.594

0.954

  1. Linear regression analyses were performed with the covariates of age, sex, education years, and JART scores. Permutation P-values, P (perm), were adjusted for multiple testing between SNPs by each BACS-J subtest P-values < 0.0083 (0.05/6) were considered as statistically significant to correct for the number of BACS-J subtests. P-values < 0.05 are in bold, and statistically significant results are marked with ‘*’.
  2. BACS-J: Brief Assessment of Cognition in Schizophrenia, Japanese-language version.