Table 4 Secondary outcome measures: comparing means between the intervention and usual care groups at 15 and 33 weeks post-randomisation
From: A pilot randomised controlled trial of cognitive behavioural therapy for antenatal depression
15 weeks post-randomisation | 33 weeks post-randomisation (in the postnatal period) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Intervention | UC | Adjusted difference in means(1) (95% CI) p value | Intervention | UC | Adjusted difference in means (1) (95% CI) p value | |||||
n | Mean (sd) | n | Mean (sd) | n | Mean (sd) | n | Mean (sd) | |||
CIS-R Scores | 16 | 12.4 (9.2) | 13 | 22.3 (11.1) | −10.0 (−16.9 to −2.9) p= 0.007 | 16 | 9.8 (8.8) | 11 | 22.4 (11.9) | −12.6 (−21.1 to −4.2) p= 0.005 |
EPDS | 16 | 7.9 (4.7) | 13 | 13.8 (7.5) | −5.9 (−10.3 to −1.5) p= 0.01 | 16 | 7.1 (4.8) | 11 | 13.7 (6.2) | −6.8 (−11.3 to −2.2) p= 0.005 |
PHQ-9 | 16 | 6.2 (4.2) | 13 | 11.8 (7.8) | −5.6 (−9.9 to −1.3) p= 0.01 | 16 | 6.2 (4.3) | 11 | 10.7 (5.8) | −4.7 (−8.8 to −0.6) p= 0.03 |
Physical component of SF12 score* | 16 | 34.5 (7.8) | 13 | 38.5 (5.8) | −4.4 (−9.5 to 0.7) p= 0.09 | 15 | 39.8 (6.9) | 11 | 44.9 (12.1) | −7.5 (−15.3 to 0.3) p= 0.06 |
Mental component of SF12 score* | 16 | 52.1 (6.4) | 13 | 42.9 (8.9) | 10.2 (4.4 to 16.0) p= 0.001 | 15 | 49.2 (4.6) | 11 | 42.8 (11.0) | 7.5 (0.9 to 14.0) p= 0.03 |
Metacognitive awareness questionnaire** | 16 | 44.7 (6.2) | 12 | 41.5 (8.1) | 5.1 (−0.3 to 10.5) p= 0.06 | 15 | 42 (5.8) | 10 | 39.7 (9.7) | 5.0 (−0.5 to 10.4) p= 0.07 |
EQ-5D* | 16 | 0.78 (0.16) | 13 | 0.72 (0.17) | 0.06 (−0.05 to 0.18) p= 0.26 | 15 | 0.90 (0.13) | 11 | 0.78 (0.11) | 0.13 (0.03 to 0.22) p= 0.01 |
Prenatal Attachment Inventory | 16 | 60.4 (3.0) | 10 | 47.2 (3.3) | 2.6 (2.69 to 22.38) p= 0.01 | - | - | - | - | - |