TY - JOUR AU - Arts, Baer AU - Simons, Claudia JP AU - Drukker, Marjan AU - van Os, Jim PY - 2013 DA - 2013/02/19 TI - Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158Met genotype JO - BMC Psychiatry SP - 63 VL - 13 IS - 1 AB - There is a negative association between the use of antipsychotics and cognitive functioning in bipolar patients, which may be mediated by altered dopamine signaling in selected brain areas, and moderation thereof by genetic sequence variation such as COMT Val108/158Met. The interaction between antipsychotic drug use and the COMT Val108/158Met genotype on two-year cognitive functioning in bipolar patients was examined. SN - 1471-244X UR - https://doi.org/10.1186/1471-244X-13-63 DO - 10.1186/1471-244X-13-63 ID - Arts2013 ER -