Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158Met genotype

Table 2 Interaction between antipsychotic medications and COMT Val/Met polymorphism (rs4680) on cognitive functioning in bipolar patients (Met/Met as reference; psychopathology and time as fixed factors)

Cognitive	Variable	Verbal	Memory	Selective	Attention	Working	Memory	Composite	Measure
N obs.		419		384		416		379
		beta	p-value	beta	p-value	beta	p-value	beta	p-value
COMT		0.24	0.511	0.63	0.053	0.5	0.051	0.42	0.036
Antipsych.		−0.03	0.932	0.64	0.087	0.05	0.858	0.19	0.367
MainInteract.		−0.79	0.091	−1.1	0.024	−0.35	0.340	−0.79	0.004
Stratified	COMT = 0			0.64	0.087			0.19	0.367
interaction	COMT = 1			−0.47	0.141			−0.59	0.001
BPRS		−0.05	0.492	−0.02	0.835	−0.05	0.396	−0.04	0.385
HDRS		0.005	0.948	0.05	0.551	0.06	0.292	0.02	0.602
YMRS		0.002	0.972	0.12	0.029	0.07	0.061	0.06	0.063
Time		0.06	0.000	0.13	0.000	0.09	0.000	0.09	0.000

ISSN: 1471-244X