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Table 1 Summary of evidence-based recommendations for clozapine prescribing

From: Clozapine: a review of clinical practice guidelines and prescribing trends

Date

Source

Recommendation: clozapine to be prescribed or offered to patients

  
  

After failure of 2 adequate trials of 2 different AAs

With suicidal thoughts or behaviours

With persistent hostility and violent behaviours

2004

APA (US) [13]

X

  

2005

CPA (CAN) [14]

X

  

2007

TMAP (US) [15]

X (SGAs considered first-line)

  

2009

NICE (UK) [16]

X (at least one of the drugs should be a non-clozapine SGA)

  

2010

Schizophrenia PORT (US) [17]

X

X

X

2010

CADTH [18]

X

  

2011

BAP (UK) [19]

X

 

X

2013

PAP (US) [20]

X (SGA, risperidone and olanzapine) considered first-line)

X

X

  1. Note: AA = antipsychotic agent, APA = American Psychiatric Association, BAP = British Association for Psychopharmacology, CADTH = Canadian Agency for Drugs and Technology in Health, CPA = Canadian Psychiatry Association, PAP = Psychopharmacology Algorithm Project, PORT = Patient Outcomes Research Team, TMPA = Texas Medication Algorithm Project.