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Table 2 Reduction protocol for high-potency drugs

From: Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan

Generic name Product name Maximum reduction rate(mg/week) Maximum reduction(mg)
Perphenazine PZC, others 5 10
Perospirone Lullan 4 8
Trifluoperazine Trifluoperazine 2.5 5
Nemonapride Emilace 2.25 4.5
Aripiprazole Abilify 2 4
Blonanserin Lonasen 2 4
Pimozide OLAP 2 4
Olanzapine Zyprexa 1.25 2.5
Bromperidol Impromen 1 2
Haloperidol Serenace, others 1 2
Fluphenazine Flumezin 1 2
Timiperone Tolopelone 0.65 1.3
Spiperone Spiropitan 0.5 1
Risperidone Risperdal, others 0.5 1
  1. Maximum reduction rate represents the maximum acceptable reduction per week.
  2. Maximum reduction represents the maximum amount of reduction at a time. After maximum reduction, subsequent reduction is performed after a minimum 2-week observation period.
  3. (Cited and partially modified from Sukegawa [11]).