Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan

BMC Psychiatry

Table 2 Reduction protocol for high-potency drugs

Generic name	Product name	Maximum reduction rate^†(mg/week)	Maximum reduction^‡(mg)
Perphenazine	PZC, others	5	10
Perospirone	Lullan	4	8
Trifluoperazine	Trifluoperazine	2.5	5
Nemonapride	Emilace	2.25	4.5
Aripiprazole	Abilify	2	4
Blonanserin	Lonasen	2	4
Pimozide	OLAP	2	4
Olanzapine	Zyprexa	1.25	2.5
Bromperidol	Impromen	1	2
Haloperidol	Serenace, others	1	2
Fluphenazine	Flumezin	1	2
Timiperone	Tolopelone	0.65	1.3
Spiperone	Spiropitan	0.5	1
Risperidone	Risperdal, others	0.5	1

^†Maximum reduction rate represents the maximum acceptable reduction per week.
^‡Maximum reduction represents the maximum amount of reduction at a time. After maximum reduction, subsequent reduction is performed after a minimum 2-week observation period.
(Cited and partially modified from Sukegawa [11]).

ISSN: 1471-244X