Study | A | B | C | D | E | Pooled A-E |
---|---|---|---|---|---|---|
Total numbers | 295 | 170 | 118 | 156 | 230 | 969 |
Prevalencea | 19.0% | 16.5% | 50.0% | 48.7% | 42.6% | 32.7% |
AUCb (95% CI) | .851 (.803; .896) | .857 (.774; .927) | .737 (.643; .820) | .787 (.714; .855) | .775 (.714; .834) | .793 (.763; .822) |
Best thresholdc (95% CI) | 7.5 (5.5; 8.5) | 8.5 (4.5; 12.5) | 5.5 (4.5; 8.5) | 4.5 (3.5; 6.5) | 7.5 (6.5; 11.5) | 6.5 (5.5; 7.5) |
- Sensitivity (95% CI) | .79 (.68; .89) | .71 (.54; .86) | .71 (.59; .83) | .75 (.64; .84) | .79 (.70; .86) | .74 (.69; .79) |
- Specificity (95% CI) | .77 (.72; .83) | .84 (.77; .89) | .63 (.51; .75) | .73 (.63; .83) | .67 (.59; .75) | .71 (.67; .75) |
- ppvd (95% CI) | .45 (.39; .52) | .47 (.36; .59) | .63 (.58; .75) | .72 (.65; .80) | .64 (.58; .70) | .55 (.52; .59) |
- npve (95% CI) | .94 (.91; .97) | .94 (.90; .97) | .69 (.60; .78) | .75 (.68; .83) | .81 (.75; .87) | .85 (.82; .87) |
Lower thresholdf (95% CI) | 5.5 (3.5; 7.5) | 4.5 (1.5; 8.5) | 2.5 (1.5; 4.5) | 1.5 (0.5; 3.5) | 3.5 (2.5; 7.5) | 3.5 (2.5; 4.5) |
- Sensitivity (95% CI) | .86 (.75; .95) | .89 (.79; 1.00) | .88 (.80; .97) | .91 (.84; .96) | .87 (.80; .93) | .87 (.83; .90) |
- Specificity (95% CI) | .68 (.62; .74) | .62 (.54; .70) | .37 (.25; .49) | .43 (.31; .54) | .42 (.33; .50) | .51 (.47; .55) |
- ppvd (95% CI) | .39 (.34; .44) | .32 (.27; .37) | .58 (.53; .64) | .60 (.55; .65) | .52 (.49; .57) | .46 (.44; .49) |
- npve (95% CI) | .95 (.92; .98) | .97 (.93; 1.00) | .76 (.61; .91) | .83 (.72; .93) | .81 (.73; .89) | .89 (.86; .92) |
Higher thresholdg (95% CI) | 10.5 (8.5; 11.5) | 9.5 (7.5; 11.5) | 9.5 (7.5; 12.5) | 8.5 (6.5; 12.5) | 15.5 (11.5; 17.5) | 10.5 (9.5; 11.5) |
- Sensitivity (95% CI) | .57 (.45; .70) | .64 (.46; .82) | .42 (.31; .56) | .50 (.38; .61) | .43 (.32; .52) | .52 (.46; .57) |
- Specificity (95% CI) | .89 (.85; .93) | .86 (.80; .92) | .86 (.78; .95) | .89 (.81; .95) | .87 (.81; .92) | .86 (.83; .89) |
- ppvd (95% CI) | .54 (.45; .65) | .47 (.36; .61) | .76 (.63; .89) | .81 (.71; .91) | .71 (.61; .82) | .65 (.59; .70) |
- npve (95% CI) | .90 (.87; .93) | .92 (.89; .96) | .60 (.54; .66) | .65 (.60; .71) | .67 (.63; .71) | .79 (.77; .81) |