Table 1 Demographic and disease characteristics of the bipolar disorder patients in the euthymic state
|  | Olanzapine (n = 20) | Lamotrigine (n = 26) |
|---|---|---|
Age (years), mean (SD) | 43.5 (11.8) | 38.8 (11.5) |
Female, n (%) | 11 (55.0) | 21 (80.8) |
Age of onset, mean (SD) | 33.0 (11.7) | 27.4 (7.6) |
Polarity of first onset | Â | Â |
Manic, Mixed episode or others, n (%) | 7 (35.0) | 4 (15.4) |
Depressive episode, n (%) | 13 (65.0) | 22 (84.6) |
Diagnosis as Bipolar I disorder, n (%)a | 13 (65.0)* | 5 (19.2)* |
Polarity of previous episodeb | Â | Â |
Manic, Mixed episode or others, n (%) | 13 (65.0) | 4 (15.4)* |
Depressive episode, n (%) | 7 (35.0) | 22 (84.6)* |
With residual affective symptoms, n (%) | 9 (45) | 8 (30.8) |
Weeks of euthymic state before enrolment, mean (SD) | 13.1 (8.9) | 10.8 (5.8) |
Number of depressive episodes, past year, mean (SD) | 0.3 (0.4) | 0.5 (0.6) |
Number of manic, mixed episodes or others, past year, mean (SD) | 0.3 (0.5) | 0.2 (0.5) |
Comorbid personality disorder, n (%) | 3 (15.0) | 9 (34.6) |
Comorbid alcohol abuse/dependence, n (%) | 4 (20.0) | 4 (15.4) |
Comorbid other psychiatric disorder (posttraumatic stress disorder, panic disorder) or medical diseases, n (%) | 4 (20.0) | 1 (3.8) |
Dosage (mg/day), mean (SD) | 10.9 (7.4) | 86.5 (49.6) |
Concomitant medications, n (%) | Â | Â |
Antidepressant(s)c | 6 (30.0)* | 18 (69.2)* |
Anxiolytic(s) | 7 (35.0) | 16 (61.5) |
Short-acting hypnotics | 20 (100) | 21 (80.8) |
Long acting hypnotics | 12 (60.0) | 17 (65.4) |
Present YMRS scored | 6.3 (5.0) | 3.3 (3.7)* |
Present HAM-D score | 4.8 (1.1) | 5.2 (1.0) |