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Table 4 Association between hazard ratio for depression recurrence and risk factors of medication and other variables based on a Cox model

From: Olanzapine is superior to lamotrigine in the prevention of bipolar depression: a naturalistic observational study

  Crude modela Multivariable modelb
  HR (95% CI) p Value HR (95% CI) p Value HR (95% CI) p Value HR (95% CI) p value
Medication         
Olanzapine Ref.   Ref.   Ref.   Ref.  
Lamotrigine 3.1 (1.0-9.3) 0.045* 3.8 (1.2-11.7) 0.020* 3.9 (1.1-12.5) 0.021* 3.8 (1.1-13.4) 0.035*
Residual affective symptoms         
No symptoms    Ref.      
With symptoms    2.6 (1.0-6.5) 0.043*     
Concomitant medication         
Without antidepressants      Ref.    
With antidepressants      0.5 (0.2-1.4) 0.209   
Bipolar subtypes         
Not Bipolar I        Ref.  
Bipolar I        1.5 (0.5-4.5) 0.453
  1. Abbreviations: CI confidence interval, HR hazard ratio.
  2. aOnly medication as the risk factor in the crude model.
  3. bBoth medication and other variables as the risk factors in the multivariate model.
  4. *p < .05.