Olanzapine is superior to lamotrigine in the prevention of bipolar depression: a naturalistic observational study

BMC Psychiatry

Table 4 Association between hazard ratio for depression recurrence and risk factors of medication and other variables based on a Cox model

	Crude model^a		Multivariable model^b
	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p value
Medication
Olanzapine	Ref.		Ref.		Ref.		Ref.
Lamotrigine	3.1 (1.0-9.3)	0.045*	3.8 (1.2-11.7)	0.020*	3.9 (1.1-12.5)	0.021*	3.8 (1.1-13.4)	0.035*
Residual affective symptoms
No symptoms			Ref.
With symptoms			2.6 (1.0-6.5)	0.043*
Concomitant medication
Without antidepressants					Ref.
With antidepressants					0.5 (0.2-1.4)	0.209
Bipolar subtypes
Not Bipolar I							Ref.
Bipolar I							1.5 (0.5-4.5)	0.453

Abbreviations: CI confidence interval, HR hazard ratio.
^aOnly medication as the risk factor in the crude model.
^bBoth medication and other variables as the risk factors in the multivariate model.
*p < .05.

ISSN: 1471-244X